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Publication Number
US-11583620-B2
Publication Date
2023-02-21
Expiration Date
Abstract
The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid. In contrast to extracorporeal carbon dioxide removal methods of the prior art (ECCCbR), the present invention employs a versatile dialysis liquid that allows to adjust the pH and buffering capacity of the dialysis liquid, to add fluids to the dialysis liquid and/or to the blood and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs. The present invention also provides regeneration and recycling of the dialysis liquid, and thus for its repeated use. The present invention is suitable for treating human or animal subjects suffering from lung failure or lung disorders.
Core Innovation
A process is provided for oxygenating blood by introducing oxygen into blood and/or into a dialysis liquid. The dialysis liquid has a pH in the range from pH 6.8 to pH 11 and comprises albumin. Oxygen introduced into the blood and/or into the dialysis fluid is introduced by means of liquid oxygen or an oxygen-enriched liquid and/or solid, where the oxygen-enriched liquid is a homogeneous liquid with molecular oxygen dissolved therein.
Oxygen-enriched blood and/or oxygen-enriching dialysis liquid is generated and the blood is contacted with the dialysis liquid via a semipermeable membrane. In this arrangement, oxygen is delivered using non-gaseous oxygen introduction formats while maintaining a dialysis liquid environment that can buffer relevant acid/base species.
A related process is described for oxygenating a dialysis liquid by introducing oxygen into the dialysis liquid to generate oxygen-enriched dialysis liquid. The oxygenated dialysis liquid includes albumin and has a pH in the range from pH 6.8 to pH 11. Oxygen is introduced into the dialysis fluid by means of liquid oxygen or an oxygen enriched liquid and/or solid, where the oxygen-enriched liquid is a homogeneous liquid with molecular oxygen dissolved therein.
Claims Coverage
Two independent claims are identified: one directed to a process for oxygenating blood and another directed to a process for oxygenating a dialysis liquid. Across these claims, four primary inventive features are specified.
Albumin-containing dialysis liquid with pH 6.8 to 11 for oxygenating blood
A process for oxygenating blood in which the dialysis liquid has a pH in the range from pH 6.8 to pH 11 and comprises albumin.
Non-gaseous liquid oxygen or oxygen-enriched homogeneous liquid with dissolved molecular oxygen
Oxygen introduced into the blood and/or into the dialysis fluid is introduced by means of liquid oxygen or an oxygen enriched liquid and/or solid, wherein the oxygen-enriched liquid is a homogeneous liquid with molecular oxygen dissolved therein.
Semipermeable membrane contacting of blood with the oxygen-containing dialysis liquid
Oxygen-enriched blood and/or oxygen-enriching dialysis liquid is generated and the blood is contacted with the dialysis liquid via a semipermeable membrane.
Oxygenating a dialysis liquid by introducing oxygen into an albumin-containing dialysis liquid
A process for oxygenating a dialysis liquid comprising introducing oxygen into the dialysis liquid, wherein the dialysis liquid has a pH in the range from pH 6.8 to pH 11 and wherein the dialysis liquid comprises albumin, thereby generating oxygen-enriched dialysis liquid.
The claim set covers oxygenation by coupling oxygen introduction via liquid oxygen or oxygen-enriched homogeneous liquids with dissolved molecular oxygen to an albumin-containing dialysis liquid within pH 6.8 to 11. For blood oxygenation, the oxygenated dialysis liquid contacts blood through a semipermeable membrane, while the separate dialysis-liquid oxygenation claim focuses on generating an oxygen-enriched dialysis liquid using the same non-gaseous oxygen introduction formats.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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