System and method for treating haemorrhagic fluid for autotransfusion
Inventors
Gadrat, Francis • Chollet, Stéphane • Picot, Sylvain • FOREST-VILLEGAS, PATRICIA
Assignees
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Publication Number
US-11583615-B2
Publication Date
2023-02-21
Expiration Date
Abstract
The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids;a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110),a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); anda first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).
Core Innovation
The invention relates to a treatment system for treating hemorrhagic fluid previously taken from a patient for the purpose of autotransfusion. The system includes a treatment unit with a tangential filtration device that comprises a filtration membrane arranged in a housing to separate an intake chamber from a discharge chamber, and the intake chamber and the discharge chamber each have an inlet and an outlet for fluids.
The treatment unit further includes a treatment pouch having an inlet and an outlet that are fluidically connected by a recirculation line to the outlet and to the inlet of the intake chamber of the filtration device, respectively. This configuration allows hemorrhagic fluid to circulate in the recirculation line in a direction going from the outlet of the treatment pouch to the inlet of the treatment pouch through the intake chamber of the filtration device.
An intake line supplies the treatment unit with hemorrhagic fluid taken for filtration through the filtration membrane to remove a filtrate comprising undesired compounds for autotransfusion. The system also provides a transfusion line fluidically connected to the recirculation line to recover treated hemorrhagic fluid contained in the treatment pouch, a discharge line connected to the outlet of the discharge chamber to discharge the filtrate, and a cleaning line connected to the inlet of the discharge chamber to convey cleaning fluid into the discharge chamber with first and second flow regulation members to control the pressure of cleaning fluid in the discharge chamber.
Claims Coverage
The provided material identifies one independent claim. It defines six inventive features centered on a tangential filtration treatment system for autotransfusion, with a recirculation-connected treatment pouch and a cleaning line arrangement for controlling pressure in the discharge chamber.
Tangential filtration treatment unit with intake and discharge chambers separated by a filtration membrane
A filtration device for tangential filtration comprising a filtration membrane arranged in a housing so as to separate an intake chamber from a discharge chamber, where the intake chamber and the discharge chamber each have an inlet and an outlet for fluids.
Recirculation line connecting treatment pouch and filtration device intake via treatment outlet and intake inlet
A treatment pouch having an inlet and an outlet fluidically connected by a recirculation line to the outlet and to the inlet of the intake chamber of the filtration device, respectively, allowing hemorrhagic fluid to circulate in the recirculation line in a direction going from the outlet of the treatment pouch to the inlet of the treatment pouch through the intake chamber of the filtration device.
Filtration via intake line to remove filtrate undesired for autotransfusion
An intake line fluidically connected to the recirculation line between the outlet of the treatment pouch and the inlet of the intake chamber of the filtration device making it possible to supply the treatment unit with hemorrhagic fluid taken for the purpose of filtration through the filtration membrane of the filtration device in order to remove from the hemorrhagic fluid a filtrate comprising compounds undesired for autotransfusion.
Transfusion line recovering treated hemorrhagic fluid from the treatment pouch through recirculation
A transfusion line fluidically connected to the recirculation line between the outlet of the treatment pouch and the inlet of the intake chamber of the filtration device making it possible to recover treated hemorrhagic fluid contained in the treatment pouch.
Discharge line removing filtrate from the filtration discharge chamber outlet
A discharge line fluidically connected to the outlet of the discharge chamber of the filtration device so as to discharge the filtrate having passed through the filtration membrane from the intake chamber.
Cleaning line conveying cleaning fluid into discharge chamber with regulated cleaning pressure via flow regulation in cleaning and discharge lines
A cleaning line fluidically connected to the inlet of the discharge chamber of the filtration device to convey cleaning fluid into the discharge chamber, and a first flow regulation member arranged to regulate the flow in the cleaning line and a second flow regulation member arranged to regulate the flow in a discharge line so as to be able to control the pressure of cleaning fluid in the discharge chamber.
The claim coverage focuses on the overall system architecture: a tangential filtration unit with housing-separated intake and discharge chambers, a recirculation line connecting the treatment pouch to the filtration device intake, and a cleaning line into the discharge chamber with two flow regulation members to control cleaning fluid pressure.
Stated Advantages
High platelet/RBC/WBC yields.
Reduced or near-zero hemolysis.
Elimination of free hemoglobin.
Low residual heparin.
Low treatment time for 500 mL, about 10 min or less (preferably ≤5 min).
Documented Applications
Treating hemorrhagic fluid previously taken from a patient for the purpose of autotransfusion.
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