Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Assignees
Publication Number
US-11576879-B2
Publication Date
2023-02-14
Expiration Date
Abstract
Disclosed herein is a multidrug pain management package to dispense two or more medicaments to treat pain comprising a primary n-polygon, and one or more concentric m-polygons, wherein each side of the n-polygon and m-polygons have at least n or m-medicament chambers capable of holding the two or more medicaments. Also disclosed herein is a multidrug pain management package comprising a disk, wherein the disk is divided into equally spaced regions, and wherein each region has chambers capable of holding medicaments. Also disclosed herein are single formulations to treat pain.
Core Innovation
The invention provides a package to dispense two or more medicaments to treat pain. The package includes a primary n-polygon shaped blister layer in which medicament chambers are arranged so that each side of the n-polygon has at least n-medicament chambers, and the n-medicament chambers are spaced away from the edge of the n-polygon at the same distance. Each medicament chamber comprises a blister layer forming a sealed chamber capable of holding the two or more medicaments.
Within the primary n-polygon, the package further includes one or more concentric m-polygons formed by placement of medicament chambers in a concentric m-polygon pattern. The first m-polygon pattern has n-1 or fewer sides, and each additional concentric m-polygon pattern has m-1 or fewer sides from the previous concentric m-polygon pattern. Each side of the m-polygon pattern has at least m-medicament chambers capable of holding the two or more medicaments of a single formulation.
The single formulation is allocated to a patient throughout a day based on a number of hours in a day divided by the number of sides of the n-polygon or the number of sides of the m-polygon pattern. The disclosed medicament chamber construction can include a rupturable layer that is ruptured by patient-applied force to release the two or more medicaments from a medicament chamber.
The package is described in the context of treating pain using patient self-administration and includes example pharmaceutical single-formulation combinations for pain management, including acetaminophen and an NSAID, with optional additional actives such as gabapentinoids.
Claims Coverage
Independent claim clm-00001 covers a multidrug pain management package dispensing two or more medicaments using an n-polygon shaped primary blister layer with spaced medicament chambers plus one or more concentric m-polygon patterns, where a single formulation is allocated throughout a day based on polygon side counts.
n-polygon primary blister layer with spaced medicament chambers
A primary n-polygon shaped blister layer, wherein each side of the n-polygon has at least n-medicament chambers capable of holding the two or more medicaments, and wherein each of the n-medicament chambers is located at the same distance and spaced away from the edge of the n-polygon and each comprises a blister layer forming a sealed chamber capable of holding the two or more medicaments.
Concentric m-polygon medicament chamber pattern with hour-based allocation
One or more concentric m-polygons formed by placement of medicament chambers in a concentric m-polygon pattern within the primary n-polygon, wherein the first m-polygon pattern has n-1 or fewer sides, each additional concentric m-polygon pattern has m-1 or fewer sides from the previous concentric m-polygon pattern, and each side has at least m-medicament chambers capable of holding the two or more medicaments of a single formulation, allocated throughout a day based on a number of hours in a day divided by the number of sides of the n-polygon or the number of sides of the m-polygon pattern.
Selectable n-polygon geometry
The n-polygon is selected from an octagon, heptagon, hexagon, pentagon, square, rectangle, or triangle.
Rupturable substrate release by patient-applied force
A blister layer includes a substrate formed over two or more medicaments, and the substrate is ruptured by patient-applied force to release the two or more medicaments from a medicament chamber.
Minimum number of concentric m-polygon patterns
The package includes at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 concentric m-polygon patterns.
Medicament chambers sized to fully contain medicaments
The medicament chambers are sized so each chamber fully contains the two or more medicaments.
COVID-19-infected patient pain management context
A method in which the claimed package is administered by a patient to manage pain while the patient is infected with COVID-19.
Overall, the claims center on a multidrug pain management package using polygon-based blister geometry, including a primary n-polygon and concentric m-polygon patterns, to organize medicament chambers and allocate a single daily formulation to a patient based on polygon side counts, with additional limitations on polygon geometry, pattern counts, chamber sizing, and patient-applied force release.
Stated Advantages
Organizes dispensing of two or more medicaments for treating pain using polygon-based blister geometry.
Allocates a single formulation throughout a day based on number of hours and polygon side counts.
Enables patient self-administration for dosing over a day.
Provides chamber release using patient-applied force rupturing a substrate, where applicable.
Documented Applications
Treating pain by dispensing two or more medicaments in the claimed package.
Administering the claimed package by a patient to manage pain while the patient is infected with COVID-19.
Interested in licensing this patent?