Systems and methods for multi-modal and non-invasive stimulation of the nervous system

Inventors

Jovanov, Emil

Assignees

University of Alabama in Huntsville

Publication Number

US-11554244-B2

Publication Date

2023-01-17

Expiration Date

2037-05-25

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Abstract

Systems and methods are provided to combine multiple stimulation modalities to significantly increase the effectiveness of non-invasive stimulation. Multiple sensor and stimulation devices and modalities can be combined into a single, compact unit that minimizes the need for additional sensors or stimulation devices. The system features several subunits, referred to as sensory and stimulation devices (SSD), that are integrated into a headphone setup. The system is controlled by a centralized controller that communicates with all of the SSDs and with an external computer system that delivers learning material synchronized with the delivery of stimulations and the collection of user responses based on physiological signals.

Core Innovation

The invention relates to systems and methods for multi-modal and non-invasive stimulation of the autonomous and central nervous system to augment neural plasticity and modify psycho-physiological states. It solves the problem of traditional non-invasive stimulation techniques that often require separate systems for each stimulation or monitoring modality, resulting in cumbersome setups and lack of integration between different types of stimulation and sensor controls.

This invention combines multiple sensor and stimulation devices and modalities into a single, compact unit, integrated into a headphone setup with several sensory and stimulation devices (SSD). The centralized controller coordinates these SSDs and communicates with an external computer to synchronize the delivery of learning material, stimulation, and collection of physiological signals, minimizing the need for additional components.

Physiological signals measured by the integrated sensors are utilized to assess and modulate the user's psychophysiological state, optimizing performance and adapting stimulation for individual users. The system allows personalized, real-time monitoring and adjustment of non-invasive stimulations—such as electrical, audio, photic, vibration, olfactory, and electromagnetic field stimulation—in order to achieve desired outcomes in cognition, relaxation, or rehabilitation.

Claims Coverage

There are two independent claims covering two inventive features: a method of providing multi-modal stimulation with user monitoring and adjustment, and a system for wearable, multi-modal, and adaptive nervous system stimulation.

Method for providing and adjusting at least two types of stimulation with user monitoring

This inventive feature encompasses a method involving: - Providing a user with at least two types of stimulation using a user-wearable device, where the stimulations include charge based stimulation and at least one of photic, olfactory, audio, electromagnetic field, or vibration stimulation. - Monitoring user responses to these stimulations with at least one sensor integrated in the wearable device. - Adjusting the stimulation types and parameters in response to the monitored physiological response, thereby enabling adaptive, feedback-driven stimulation delivery.

Wearable system with integrated multi-modal stimulation, user monitoring, and adaptive control

This inventive feature claims a system comprising: - A user-worn device with at least one electrode for charge based stimulation and at least one sensory and stimulation device (SSD) for a second type of stimulation (photic, olfactory, audio, electromagnetic field, or vibration). - At least one sensor located on the device to monitor at least one physiological parameter of the user in response to both stimulation modalities. - A control unit communicating with these components, configured to adjust both types of stimulation based on the user's monitored physiological parameters, supporting personalized and adaptive modulation.

The claims cover both the method and system for integrated, multi-modal, and non-invasive stimulation with real-time monitoring and adaptive adjustment, all within a compact, wearable device.

Stated Advantages

The system increases the effectiveness of non-invasive stimulation by combining multiple modalities and minimizing the need for additional sensors or stimulation devices.

It allows augmentation of cognition, recovery from traumatic brain injury or stroke, implementation of relaxation techniques, and changing a state of consciousness.

The device can improve performance or change the psychophysiological state of the user.

Physiological sensing and stimulation can be personalized to each user for optimized assessment and intervention.

Documented Applications

Augmentation of cognition and improvement of cognitive performance through real-time monitoring and adaptive stimulation.

Facilitation of recovery from traumatic brain injury or stroke by providing non-invasive, multi-modal stimulation synchronized with learning or rehabilitation exercises.

Implementation of relaxation techniques, such as inducing a deeply relaxed state using multimodal stimulation and physiological entrainment.

Changing a state of consciousness using personalized and controlled sensory stimulation.

Treatment support for post-traumatic stress disorder desensitization and reprocessing.

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