Methods for delivery of therapeutic materials to treat cancer
Inventors
Agah, Ramtin • QURESHI, Imtiaz L. • Najmabadi, Kamran • BAGAI, Shaun R.
Assignees
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Publication Number
US-11541211-B2
Publication Date
2023-01-03
Expiration Date
Abstract
Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
Core Innovation
The disclosed invention provides a localized method of treatment for cholangiocarcinoma using a catheter inserted into a bile duct. The bile duct is occluded with a first occluder on a distal end region of the catheter and a second occluder on the distal end region of the catheter proximal to the first occluder, thereby isolating a region of the bile duct including the cholangiocarcinoma.
A guidewire is passed through a lumen of the catheter to focally perforate a tissue within the isolated region before delivering a therapeutic agent. After focally perforating the tissue, the therapeutic agent is delivered into the isolated region of the bile duct including the cholangiocarcinoma.
The method includes maintaining a pressure in the isolated region of the bile duct to diffuse the therapeutic agent into the cholangiocarcinoma within the bile duct. In related embodiments, the therapeutic agent is delivered into the isolated region of the bile duct from an opening in a side wall of the catheter between the first occluder and the second occluder, whereby the therapeutic agent diffuses into the cholangiocarcinoma within the bile duct.
Claims Coverage
The provided partial content includes three independent method claims. Across these independent claims, the inventive features focus on dual-occluder isolation of a bile-duct region containing cholangiocarcinoma, guidewire-based focal perforation, therapeutic agent delivery into the isolated region, and diffusion of the therapeutic agent into the cholangiocarcinoma with pressure maintenance and/or side-wall delivery between the occluders.
Dual occluder bile-duct isolation for cholangiocarcinoma region
occluding the bile duct with a first occluder on a distal end region of the catheter and a second occluder on the distal end region of the catheter proximal to the first occluder to isolate a region of the bile duct including the cholangiocarcinoma
Guidewire-based focal perforation within isolated region
passing a guidewire through a lumen of the catheter to focally perforate a tissue within the isolated region before delivering a therapeutic agent
Therapeutic agent delivery into isolated bile-duct region
delivering the therapeutic agent into the isolated region of the bile duct including the cholangiocarcinoma
Pressure maintained to diffuse therapeutic agent into cholangiocarcinoma
maintaining a pressure in the isolated region of the bile duct to diffuse the therapeutic agent into the cholangiocarcinoma within the bile duct
Side-wall opening delivery between first and second occluders
delivering the therapeutic agent into the isolated region of the bile duct from an opening in a side wall of the catheter between the first occluder and the second occluder whereby the therapeutic agent diffuses into the cholangiocarcinoma within the bile duct
Across the independent claims, the core coverage centers on isolating a bile-duct region containing cholangiocarcinoma using two occluders on the catheter, using a guidewire to focally perforate tissue within the isolated region before delivery, delivering a therapeutic agent into the isolated region, and promoting diffusion into cholangiocarcinoma by maintaining pressure and/or delivering through a side-wall opening between the occluders.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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