Compact device for detection of nanoscale analytes
Inventors
Turner, Robert • Madsen, James • Yang, Kai • HINESTROSA SALAZAR, Juan Pablo • Krishnan, Rajaram • Simon Herrera, Pedro David
Assignees
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Publication Number
US-11534756-B2
Publication Date
2022-12-27
Expiration Date
Abstract
Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.
Core Innovation
The invention relates to a compact device for isolating nanoscale analytes in a sample. The compact device includes a housing that comprises an optical pathway and is configured to receive a fluidic cartridge, and the fluidic cartridge is drawn through by a fluid-moving mechanism to process the sample in the cartridge.
The compact device further includes an electronic chip comprising a plurality of alternating current (AC) electrodes configured to be selectively energized to establish dielectrophoretic (DEP) high field and DEP low field regions. The DEP regions are produced with an alternating current having at least 5 volts and at least 3 kHz, enabling isolation of nanoscale analytes from the sample.
The compact device includes a power source provided by a portable computing device, where output from the power source is less than 5 watts. The compact device is configured to be controlled by the portable computing device, and the platform supports an integrated workflow that couples the compact device to mobile computing device/camera-based detection through the housing’s optical pathway.
Claims Coverage
The independent claim covers a compact, portable computing-device-powered platform that isolates nanoscale analytes using selectively energized AC electrodes that generate DEP high-field and DEP low-field regions, with a housing that includes an optical pathway and receives a fluidic cartridge driven by a fluid-moving mechanism. Three inventive features are identified.
Housing with optical pathway receiving a fluidic cartridge
A housing comprising an optical pathway, wherein the housing is configured to receive a fluidic cartridge comprising a fluid-moving mechanism that draws fluid through the fluidic cartridge.
Selectively energized AC electrodes generating DEP high-field and low-field regions
An electronic chip comprising a plurality of alternating current (AC) electrodes configured to be selectively energized to establish dielectrophoretic (DEP) high field and DEP low field regions produced with an alternating current having at least 5 volts and at least 3 kHz.
Portable computing device power source under less than 5 watts
A power source provided by a portable computing device, wherein output from the power source is less than 5 watts.
Portable computing device control of the compact device
Wherein the compact device is configured to be controlled by the portable computing device.
The inventive coverage is directed to integrating a housing with an optical pathway and a fluidic cartridge driven by a fluid-moving mechanism, together with selectively energized AC electrodes that generate DEP high-field and DEP low-field regions at specified AC conditions, all powered and controlled by a portable computing device under less than 5 watts.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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