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Publication Number
US-11534227-B2
Publication Date
2022-12-27
Expiration Date
Abstract
According to some embodiments, a method of confirming successful ablation of targeted cardiac tissue of a subject using a high-resolution mapping electrode comprises pacing said cardiac tissue at a predetermined pacing level to increase the heart rate of the subject from a baseline level to an elevated level, the predetermined pacing level being greater than a pre-ablation pacing threshold level but lower than a post-ablation pacing threshold level, delivering ablative energy to the ablation electrode, detecting the heart rate of the subject, wherein the heart rate detected by the high-resolution mapping electrode is at the elevated level before the post-ablation pacing threshold level is achieved, and wherein the heart rate detected by the high-resolution mapping electrode drops below the elevated level once ablation achieves its therapeutic goal or target, and terminating the delivery of ablative energy to the ablation electrode after the heart rate drops below the elevated level.
Core Innovation
The invention relates to an energy delivery module for delivering ablative energy to targeted cardiac tissue of a subject and for confirming successful ablation using a high-resolution electrode positioned along a distal end of a catheter. The high-resolution electrode comprises a distal portion and a proximal portion, and the distal and proximal portions function as a single electrode when ablative energy is delivered to targeted cardiac tissue adjacent the high-resolution electrode. The distal and proximal portions are operatively coupled to each other using at least one filtering element.
The processor increases the heart rate of the subject from a baseline level to an elevated level by delivering a predetermined pacing signal provided to the catheter by a pacemaker. The predetermined pacing signal comprises a pacing level greater than a pre-ablation pacing threshold level, and the processor terminates the delivery of ablative energy after loss of capture of the heart of the subject.
The disclosed configurations include a kit and a generator that implement the same confirmation approach, where ablative energy is delivered to a high-resolution electrode and paced heart-rate behavior is used to confirm ablation. The distal and proximal portions of the high-resolution electrode are coupled using at least one filtering element, and the system is configured to deliver the predetermined pacing signal from the pacemaker to increase heart rate above the pre-ablation pacing threshold level and to terminate energy delivery after loss of capture.
Claims Coverage
Independent claims include an energy delivery module, a kit, and a generator. The inventive features include coupling a distal-proximal high-resolution electrode with filtering elements, and using a predetermined pacing signal from a pacemaker to raise heart rate above a pre-ablation pacing threshold and terminate energy delivery after loss of capture.
Pacing-controlled ablation confirmation with termination upon loss of capture
A processor is configured to use a predetermined pacing signal provided to the catheter by a pacemaker to increase the heart rate of the subject from a baseline level to an elevated level, where the predetermined pacing signal comprises a pacing level greater than a pre-ablation pacing threshold level, and to terminate the delivery of ablative energy after loss of capture of the heart of the subject.
High-resolution electrode as distal and proximal portions operatively coupled using filtering elements
A high-resolution electrode comprises a distal portion and a proximal portion that function as a single electrode when ablative energy is delivered to targeted cardiac tissue, where the distal and proximal portions are operatively coupled to each other using at least one filtering element.
Energy delivery module coupled to a catheter to selectively ablate targeted cardiac tissue adjacent the high-resolution electrode
An energy delivery module is configured to operatively couple to a catheter and to energize a high-resolution electrode positioned along a distal end of the catheter to selectively ablate targeted cardiac tissue adjacent the high-resolution electrode.
Kit including catheter and energy delivery module configured for pacing-based confirmation
A kit includes a catheter comprising a high-resolution electrode along a distal end of the catheter and an energy delivery module with a processor regulating delivery of ablative energy, where the processor uses a predetermined pacing signal provided to the catheter by a pacemaker to increase heart rate above a pre-ablation pacing threshold level and terminates delivery after loss of capture.
Generator delivering energy to a high-resolution electrode with pacing-based confirmation
A generator comprises an energy delivery module configured to generate ablative energy for delivery to an ablation device and a processor configured to regulate delivery of ablative energy from the energy delivery module to a high-resolution electrode of the ablation device, where the processor uses a predetermined pacing signal provided by a pacemaker to increase heart rate above a pre-ablation pacing threshold level and terminates delivery after loss of capture.
The independent claims collectively cover pacing-based confirmation of successful cardiac tissue ablation by energizing a high-resolution distal-proximal electrode operatively coupled via at least one filtering element and using a pacemaker-provided predetermined pacing signal to elevate heart rate above a pre-ablation pacing threshold and terminate ablative energy delivery after loss of capture.
Stated Advantages
Provides confirmation of successful ablation of targeted cardiac tissue using loss of capture following pacing-induced heart-rate elevation.
Documented Applications
Delivering ablative energy to targeted cardiac tissue of a subject and confirming successful ablation using high-resolution mapping electrodes with pacing control.
Use in an energy delivery module, a kit for delivering ablative energy, and a generator for delivering ablative energy while confirming successful ablation.
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