Marine extract compositions and methods of use
Inventors
Assignees
Marine Biology & Environmental Technologies LLC • Commercial Marine Biology Institute LLC
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Publication Number
US-11523982-B2
Publication Date
2022-12-13
Expiration Date
Abstract
Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts. Production of collagen, elastin and hyaluronic acid are increased after application of the compositions.
Core Innovation
The invention relates to a topical skin treatment using marine extracts that are suitable for dermatologic application. The extracts are presented as stimulating fibrocytes/fibroblasts and Langerhans-cell/T-cell pathways, linking marine-derived compositions to dermal structural and cellular responses.
A therapeutically effective topical composition is described using a first tissue extract from abalone and a second tissue extract from sea cucumber, where the tissue extracts are lyophilized. The composition is presented as treating a subject affected with rosacea, with described outcomes including improved skin appearance and dermal changes.
The document further reports increases in collagen, elastin, and hyaluronic acid, and promotes dermal thickening, reduced fine lines/wrinkles/sagging, and rosacea improvement. Histology and appearance outcomes are described as showing increased fibrocytes and new blood vessels after topical treatment versus an untreated control.
Claims Coverage
The partial content includes one independent claim (clm-00001). It covers a lyophilized abalone tissue extract combined with a lyophilized sea cucumber tissue extract, formulated for dermatologic topical use with therapeutic effectiveness to treat rosacea.
Lyophilized abalone and sea cucumber tissue extract topical composition for rosacea
A topical composition suitable for dermatologic application comprising a first tissue extract from abalone and a second tissue extract from sea cucumber, wherein the first tissue extract and the second tissue extract are lyophilized, and wherein the first tissue extract and the second tissue extract are present at concentrations such that the composition is therapeutically effective to treat a subject affected with rosacea.
Therapeutically effective daily topical rosacea treatment with defined improvement/disappearance outcome
A rosacea treatment concept in which daily application of the topical composition to affected skin for 30 days produces a significant improvement or disappearance of rosacea.
Specified sea cucumber species selection
The sea cucumber tissue extract is produced from a sea cucumber selected from Holothuria mexicana, Holothuria californica, Holothuria scabra, Stichopus chlorontus, Stichopus horrens, Stichopus japonicus, Apostichopus japonicus, or Cucumaria japonica.
Polar-solvent extraction to produce the sea cucumber extract
The second tissue extract is produced by extraction using a polar solvent optionally selected from dimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, or acetic acid.
DMSO-produced sea cucumber extract increases skin components and new blood vessels
A dermatologically suitable topical composition in which the second tissue extract is produced by extracting with dimethyl sulfoxide (DMSO), and applying the composition increases production of collagen, elastin, hyaluronic acid, fibrocytes, and new blood vessels.
Overall, the claim coverage centers on a dermatology-suitable, lyophilized topical composition combining an abalone tissue extract and a sea cucumber tissue extract at therapeutically effective concentrations to treat rosacea, with dependent refinements specifying daily topical treatment outcomes, selected sea cucumber species, polar-solvent extraction (including DMSO), and claimed increases in collagen, elastin, hyaluronic acid, fibrocytes, and new blood vessels.
Stated Advantages
Therapeutically effective treatment of a subject affected with rosacea.
Significant improvement or disappearance of rosacea after daily use for a defined period.
Increased production of collagen, elastin, hyaluronic acid, fibrocytes, and new blood vessels.
Documented Applications
Topical dermatologic application to treat rosacea in a subject using a topical composition comprising lyophilized abalone and lyophilized sea cucumber tissue extracts.
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