Foam compositions, foam matrices and methods
Inventors
Dudnyk, Vyacheslav • KANOATOV, Mirzo • DiTizio, Valerio
Assignees
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Publication Number
US-11517644-B2
Publication Date
2022-12-06
Expiration Date
Abstract
Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.
Core Innovation
The invention relates to a dried, cross-linked foam matrix that includes a biomolecule selected from gelatin, collagen, elastin, and combinations thereof, and a biocompatible polymer selected from polyethylene glycol, poly-L-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate, pectin, cellulose, carboxymethylcellulose, and mixtures thereof. The biomolecule and the biocompatible polymer are evenly distributed throughout the matrix, and the matrix further includes an active agent.
The matrix is non-lyophilized and is characterized by defined composition and performance, including a biomolecule content of about 40% to about 80% (w/w) by weight of the matrix. The dried, cross-linked foam exhibits an absorption capacity of about 20 times to about 50 times a dry weight of the matrix.
The document further characterizes embodiments by defining the foam matrix structure and composition, including even distribution of the biomolecule and biocompatible polymer, and optional specification of pore size and thickness. The active agent is incorporated into the matrix, and the document discusses cross-linked, air-dried biomolecule-based porous wound-dressing matrices that avoid a hardened or compacted “skin” associated with comparative approaches.
Claims Coverage
The independent claim covers a dried, cross-linked foam matrix that is non-lyophilized, with evenly distributed biomolecule and biocompatible polymer phases and an incorporated active agent. It recites four main inventive elements: specific biomolecule and biocompatible polymer selections, even distribution throughout the matrix, the dried non-lyophilized cross-linked foam structure, and quantitative composition/performance relating to biomolecule content and absorption capacity.
Evenly distributed biomolecule and biocompatible polymer foam matrix
A matrix comprising a biomolecule selected from gelatin, collagen, elastin, and combinations thereof, and a biocompatible polymer selected from polyethylene glycol, poly-L-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate, pectin, cellulose, carboxymethylcellulose and mixtures thereof, wherein the biomolecule and biocompatible polymer are evenly distributed throughout the matrix.
Dried cross-linked non-lyophilized foam matrix
A dried, cross-linked foam matrix that is non-lyophilized.
High biomolecule loading in the dried cross-linked foam
The biomolecule is present at about 40% to about 80% (w/w) by the weight of said matrix.
High absorption capacity of the non-lyophilized foam
The matrix has an absorption capacity of about 20 times to about 50 times a dry weight of the matrix, and the matrix comprises an active agent.
Across the independent claim, coverage centers on a non-lyophilized dried, cross-linked foam matrix with evenly distributed biomolecule and biocompatible polymer and an active agent, featuring biomolecule content about 40% to about 80% (w/w) and absorption capacity about 20 to about 50 times dry weight. Dependent claims further refine matrix structure and composition and specify example active agent selections, crosslinking agent selections, and additional physical parameters.
Stated Advantages
High absorption capacity, about 20 times to about 50 times a dry weight of the matrix.
Avoidance of a hardened or compacted “skin” associated with comparative approaches.
Supports reducing microorganism growth, as discussed in the document.
Documented Applications
Wound treatment using porous wound-dressing matrices formed as dried, cross-linked foam matrices.
Microorganism growth reduction using matrices including an active agent, as evaluated in antimicrobial activity testing.
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