Topical formulations containing erythritol and methods of treating skin conditions
Inventors
Assignees
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Publication Number
US-11517578-B1
Publication Date
2022-12-06
Expiration Date
Abstract
Embodiments include formulations and methods for topical administration of sugar alcohol to treat a skin condition such as acne. A formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. The sugar alcohol can be erythritol. The erythritol can be administered with zinc chloride. The erythritol and zinc chloride can be formulated at a molar ratio of about 3:1. The methods can also include administration of a therapeutic amount of a second agent such as benzoyl peroxide or a retinoid.
Core Innovation
The disclosed invention relates to methods of treating topical/transdermal acne and other bacterial skin-condition treatments by administering a therapeutic amount of erythritol and zinc to a subject. The erythritol and zinc are provided at a molar ration of about 3:1, and the administration is associated with ameliorating acne in the subject.
The invention also relates to inhibiting growth of Cutibacterium acnes by administering a therapeutic amount of a formulation to the subject. The formulation includes a moisturizer, an emollient, erythritol, zinc chloride, and water, and can optionally be administered with one or more additional acne/dermatologic therapeutic agents.
In addition, the disclosure includes embodiments in which one or more second acne agents are co-administered or otherwise added alongside the erythritol and zinc components. The second agents are identified as including benzoyl peroxide, a retinoid, a steroid, an antibiotic, azelaic acid, salicylic acid, dapsone, a contraceptive, an anti-androgen agent, and isotretinoin.
Claims Coverage
The partial content includes two independent claims covering (i) a method of ameliorating acne using therapeutic erythritol and zinc at a specified molar ration, and (ii) a method of inhibiting growth of Cutibacterium acnes using a topical formulation with specified component percentages. Across these independent claims, there are two core inventive features.
Erythritol and zinc at a specified molar ratio for ameliorating acne
A method of ameliorating acne in a subject comprising administration of a therapeutic amount of erythritol and zinc to the subject, wherein the erythritol and zinc are at a molar ration of about 3:1.
Topical formulation with specified erythritol and zinc chloride percentages to inhibit Cutibacterium acnes growth
A method of inhibiting growth of Cutibacterium acnes in a subject by administration of a therapeutic amount of a formulation to the subject, wherein the formulation comprises a moisturizer, an emollient, erythritol, zinc chloride, and water.
Taken together, the claims cover acne treatment by therapeutic administration of erythritol and zinc at a molar ration of about 3:1, and acne/bacterial targeting via a formulation containing erythritol and zinc chloride with moisturizer, emollient, and water. Dependent claim coverage further supports topical administration and optional co-administration of adjunct medicaments and optional formulation additives.
Stated Advantages
Ameliorating acne in a subject.
Inhibiting growth of Cutibacterium acnes in a subject.
Documented Applications
Treating acne in a subject using erythritol and zinc at a specified molar ration.
Inhibiting growth of Cutibacterium acnes in a subject using a therapeutic formulation containing erythritol and zinc chloride.
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