Cardiac compression device having passive and active chambers
Inventors
Criscione, John C. • Harrison, Lewis D. • Moreno, Michael R. • Bolch, Christina M. • Robbins, Dennis I. • Biswas, Saurabh • Leschinsky, Boris
Assignees
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Publication Number
US-11511102-B2
Publication Date
2022-11-29
Expiration Date
Abstract
The present invention provides methods, systems, kits, and cardiac compression devices that have both passive chambers and active chambers to improve heart function.
Core Innovation
The invention is a direct cardiac compression device adapted to surround a heart. It includes inner passive chambers that provide adjustable passive support, with an inner membrane and a connecting membrane, and passive fluid deposited in the inner passive chambers. The inner passive chambers conform to the shape of the heart and are adjustable to reduce the volume of the heart without inverting the curvature of the heart.
The device also includes outer active chambers adapted to at least partially surround the inner passive chambers. The outer active chambers include an outer member in communication with the connecting membrane and active fluid disposed in the outer active chambers, and the active fluid increases in pressure and presses on the inner passive chambers which in turn compress the heart.
The document describes the device architecture as supporting synchronous assist through adjustable passive support and active assist, while maintaining a nonobligatory operation concept when inactive. It further describes maintaining heart curvature without inversion and includes performance rationale using leftward shifts in EDPVR with passive support and decompression with active assist.
Claims Coverage
The independent claims collectively define a direct cardiac compression device with four inventive features: inner passive chambers that conform to the heart and reduce heart volume without inverting curvature, outer active chambers that apply compressive pressure via an active fluid, fluid communication through input/output connections, and chamber partitioning and membrane relationships.
Inner passive chambers conform to heart shape without inverting curvature
An inner passive chambers comprising an inner membrane and a connecting membrane in communication, with a passive fluid deposited in the inner passive chambers, where the inner passive chambers conform to the shape of the heart and are adjustable to reduce the volume of the heart without inverting the curvature of the heart.
Outer active chambers apply compressive pressure through active fluid
An outer active chambers comprising an outer member in communication with the connecting membrane to form outer active chambers, and an active fluid disposed in the outer active chambers, wherein the active fluid increases in pressure and presses on the inner passive chambers which in turn compress the heart.
Outer active chambers press on connecting membrane to compress heart
An outer active chambers comprising an outer member in communication with the connecting membrane to form outer active chambers, and an active fluid disposed in the outer active chambers, wherein the active fluid is adapted to press on the connecting membrane to compress the heart when the active fluid is increased in volume.
Active fluid ingress and egress through input/output connections
Outer active chambers including an input connection in fluid communication with the outer active chambers to ingress the active fluid into the outer active chambers, and an output connection in fluid communication with the outer active chambers to egress the fluid from the outer active chambers, wherein the active fluid presses on the inner passive chambers to compress the heart.
Across the independent claims, the core claim coverage centers on a two-layer direct cardiac compression architecture: inner passive chambers that conform to the heart to adjust volume reduction without inverting curvature, and outer active chambers that use an active fluid to press on the inner passive chambers to compress the heart, with fluid delivery and withdrawal defined by input/output connections in one independent claim.
Stated Advantages
Adjustable passive support to reduce the volume of the heart.
Reduces the volume of the heart without inverting the curvature of the heart.
Active fluid increases in pressure and presses on the inner passive chambers which in turn compress the heart.
Compressive pressure is applied to change end-systolic and/or end-diastolic configurations by applying varying and/or uniform pressure to the surface of a heart.
Documented Applications
Testing described using an esmolol-induced acute heart failure model (ovine model) with pressure-volume loops and comparative outcomes for passive support and active assist.
Device operation described in terms of synchronously assisting heart motion/output while maintaining nonobligatory operation when inactive.
Monitoring and assessment described using passive fluid pressure waveform concepts and related sensor/monitoring concepts.
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