Dermal patch for collecting a physiological sample
Inventors
Nawana, Namal • Al-Shamsie, Ziad Tarik
Assignees
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Publication Number
US-11510602-B1
Publication Date
2022-11-29
Expiration Date
Abstract
A dermal patch for collecting a physiological sample includes a housing with a collection chamber, a sample channel and a pin within a receptacle of the housing. The sample channel is configured to direct a physiological sample drawn from a subject to the collection chamber. The pin is removably positioned within the receptacle and is configured to move from an undeployed position to a deployed position. The pin is configured to seal the receptacle when in the undeployed position and is further configured to facilitate generation of negative pressure in the sample channel when the pin is moved from the undeployed to the deployed position.
Core Innovation
The invention relates to a dermal patch for collecting a physiological sample. The dermal patch includes a housing having a collection chamber and a sample channel configured to direct a physiological sample drawn from a subject to the collection chamber. The housing also includes a pin removably positioned in a receptacle so that the pin seals the receptacle when within the recepticle.
A key aspect is that the pin is further configured to facilitate generation of negative pressure in the sample channel when the pin is removed from the receptacle. The negative pressure arrangement supports drawing and directing the physiological sample into the collection chamber via the sample channel. Access to the subject is supported through a puncturable septum and a lancet to access the subject's skin when adhered.
The dermal patch further supports optional processing-fluid and downstream detection and information handling. A processing-fluid reservoir is released by a user-actuated slider, with processing fluid delivered through processing fluidic channels and mixed with the collected sample in the chamber. The patch supports optional capture on absorbent elements and includes multiple detector modalities for detecting/quantifying target analytes, and can integrate with computing for signal processing and electronic medical record updates, including QR code association and automated EMR updates in a metaverse/cloud-enabled framework.
Claims Coverage
The independent claim identifies a dermal patch architecture with a housing, collection chamber, sample channel, and a removably positioned pin that seals the receptacle and enables negative pressure generation in the sample channel when removed. The disclosed dependent claim coverage refines the access, processing-fluid handling, and detector/analyte aspects, and adds sample absorbent and information-handling components.
Negative-pressure-enabled dermal patch sampling
A dermal patch for collecting a physiological sample includes a housing with a collection chamber, a sample channel configured to direct a physiological sample drawn from a subject to the collection chamber, and a pin removably positioned in a receptacle wherein the pin seals the receptacle when disposed within the recepticle and facilitates generation of negative pressure in the sample channel when the pin is removed from the receptacle.
Puncturable septum with lancet skin access
The dermal patch includes an opening covered by a puncturable septum that is pierced by a lancet to access the subject's skin when adhered.
Processing fluid released by user-actuated slider
The dermal patch includes a processing-fluid reservoir released by a user-actuated slider, with processing fluidic channel delivery enabling mixing of the processing fluid with the collected sample in the chamber.
Processing fluid with anti-coagulant
The dermal patch processing fluid contains an anti-coagulant.
Anti-coagulant selected as heparin or protease inhibitor
The dermal patch includes an anti-coagulant that is heparin or a protease inhibitor.
Multiple detector modalities for target analytes
A detector is selected as a lateral flow detector, an electrochemical detector, or a graphene-based detector.
Absorbent element includes nitrocellulose strip
An absorbent element includes a nitrocellulose strip.
Overall, the claim set centers on a dermal patch sampling mechanism using a negative-pressure-generating pin with a housing/collection chamber and sample channel, and further covers puncturable septum/lancet access, optional processing-fluid reservoir release and mixing, anti-coagulant processing fluid, detector selection among lateral flow/electrochemical/graphene-based options, and absorbent collection elements including a nitrocellulose strip.
Stated Advantages
Facilitates generation of negative pressure in the sample channel when the pin is removed from the receptacle.
Supports detection/quantification of target analytes using selected detector modalities.
Optional serum separation is described as improving sensitivity/specificity.
Enables integration with computing for signal processing, QR code association, and automated EMR updates.
Supports capture on absorbent elements for downstream detection.
Documented Applications
Collecting physiological samples from a subject using a dermal patch for subsequent processing and detection of target analytes, including biomarkers and pathogens.
Performing analyte detection using lateral flow, electrochemical, and graphene-based detector modalities.
Association of sample results with an electronic medical record database using a QR code and automated EMR updates.
A cloud-enabled, metaverse/network-based control/notification framework for the patch and its associated systems.
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