Cellular therapy infusion devices, systems, and methods for use

Inventors

Joshi, Nikhil • Foley, Marcus • Thakor, Avnesh

Assignees

Cellular Vehicles Inc

Abstract

Cellular therapy infusion devices for the delivery of media including cellular therapies to a patient's tissue, cells, and/or blood include a barrel, a plunger that fits within the barrel, a syringe shaft, and a pressure relief system configured to achieve and/or maintain a desired level of pressure and/or force within the device so that cellular behavior and/or viability is not adversely impacted by the mechanical forces exerted thereon via depressing the plunger into the barrel so the cellular therapy media may be pushed from the barrel into a patient delivery device for administration to the patient. The cellular therapy infusion devices may cooperate with and/or fit into cellular therapy infusion systems designed to create and/or maintain preferred conditions for the cellular therapy media stored in the barrel and automatically administer the cellular therapy media from the cellular therapy infusion device to the patient in a steady, regulated, and/or preferred manner.

Core Innovation

The invention describes a cellular therapy infusion device that includes a barrel sized and shaped to accept insertion of a plunger and to contain a volume of cellular therapy media. A syringe shaft has a first end physically coupled to and in liquid communication with the barrel and a second end including a catheter coupling configured to couple to a catheter. Translating the plunger from a first position to a second position applies force to the volume of cellular therapy media to push the cellular therapy media from the barrel into the syringe shaft.

The device further includes a pressure relief system including a diaphragm physically coupled to and in communication with the syringe shaft, where the diaphragm is configured to expand in shape when a force is exerted thereon to absorb pressure within at least one of the syringe shaft and the barrel. In system configurations, an endplate accepts and holds the cellular therapy infusion device in place and includes a catheter exit port arranged to allow the catheter coupled to the cellular therapy infusion device to exit via the catheter exit port.

In a cellular therapy infusion system, the invention also includes a motor moving a headplate mechanically coupled thereto, where the headplate applies a steady compressive force to the plunger responsively to movement of the motor to translate the plunger from the first position to the second position. Temperature monitoring and control is described via a thermometer and a heat source that generates heat in response to the temperature measured by the thermometer, and an agitation mechanism is described as configured to agitate the volume of cellular therapy media.

Claims Coverage

This patent portion includes three independent claims covering a cellular therapy infusion device with a plunger-driven barrel-to-syringe transfer and diaphragm-based pressure relief, a similar infusion device that further allows the barrel to rotate around a stationary syringe shaft, and a cellular therapy infusion system that incorporates the infusion device into an endplate-based system with a motor-driven headplate and optional thermal/agitation subsystems. Across these independent claims, the core coverage centers on plunger translation force transfer and diaphragm expansion pressure absorption, with additional coverage for rotational coupling in one device claim and system-level mechanical delivery and subsystem elements in the system claim.

Overall, the independent claims cover a cellular therapy infusion device/system where plunger translation forces cellular therapy media from a barrel into a syringe shaft coupled to a catheter, with diaphragm expansion configured to absorb pressure within the syringe shaft and/or barrel. One independent device claim further requires a coupling that permits barrel rotation around a stationary syringe shaft, while the independent system claim requires endplate catheter exit port functionality and motor-driven steady compressive force applied to translate the plunger.

Stated Advantages

Documented Applications