Neuroprotection and neuroregeneration by pterostilbene and compositions thereof
Inventors
Ichim, Thomas E. • Dixon, Timothy G. • Veltmeyer, James
Assignees
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Publication Number
US-11504410-B2
Publication Date
2022-11-22
Expiration Date
Abstract
Disclosed are means, compositions of matter, and protocols useful for neuroprotection and neuroregeneration. In one embodiment the invention provides administration of pterostilbene alone or in combination with other ingredients to induce neuroprotection and/or neuroregeneration. The invention teaches protection/regeneration in conditions associated with neurological inflammation and/or other congenital or acquired neurodegenerative diseases.
Core Innovation
The invention provides a method of protecting from damage and/or of regenerating a neurological tissue by administering pterostilbene and/or blueberry and/or an extract thereof, green tea and/or an extract thereof, Nigella sativa and/or an extract thereof, and broccoli and/or an extract thereof. The compositions are described as pterostilbene-based and are administered alone or in combination with nutraceuticals and/or their extracts, including green tea/EGCG or analogues, blueberry/pterostilbene or analogues, Nigella sativa/thymoquinone or analogues, and broccoli/sulforaphane or analogues.
The invention further describes neuroprotection via inhibition of neuronal apoptosis, neuronal dysfunction, neuronal excitotoxicity, and neuronal oxidative stress. Mechanistic details include modulation of apoptosis-related signaling such as Bcl-2 upregulation and Fas/FasL downregulation, and associated reduction of neuroinflammation mechanisms, including microglial activation and complement activation, including TNF-alpha suppression.
For neuroregeneration, the invention describes stimulating axonal re-connections and proliferation of endogenous neural progenitor cells and/or exogenous neural progenitor cells. Endogenous neural progenitor cell sources described include subventricular zone and dentate gyrus/hippocampus regions.
Claims Coverage
The independent claim identifies one core inventive concept: a method for protecting from damage and/or regenerating neurological tissue by administering a combination of four specified nutraceuticals or their extracts. Across the dependent claims, the document refines the protective and regenerative mechanisms and specifies regenerative stimulation and sources of endogenous neural progenitor cells.
Multi-nutraceutical administration for neurological protection and regeneration
A method of protecting from damage and/or of regenerating a neurological tissue, comprising administration of pterostilbene and/or blueberry and/or an extract thereof; green tea and/or an extract thereof; Nigella sativa and/or an extract thereof; and broccoli and/or an extract thereof.
Neuroprotection via inhibition of neuronal apoptosis
Neurological protection is implemented by inhibiting neuronal apoptosis.
Neuroprotection via upregulating Bcl-2
Neurological protection is achieved by upregulating Bcl-2.
Neuroregeneration via stimulating axonal re-connections
Regeneration of the neurological tissue is achieved by stimulating axonal re-connections.
Neuroregeneration via proliferation of endogenous neural progenitor cells
Regeneration includes proliferation of endogenous neural progenitor cells.
Endogenous neural progenitor cells from the subventricular region
Endogenous neural progenitor cells originate from the subventricular region.
Broccoli extract comprising sulforaphane or an analogue
The broccoli extract is sulforaphane or an analogue of sulforaphane.
Overall, the claims cover administering pterostilbene/blueberry, green tea, Nigella sativa, and broccoli or their extracts for protecting neurological tissue from damage and/or regenerating it, with further refinements describing neuroprotection through inhibition of neuronal apoptosis and Bcl-2 upregulation, and neuroregeneration through stimulating axonal re-connections and proliferation of endogenous neural progenitor cells, including a specified endogenous source and a specified broccoli extract component.
Stated Advantages
Protecting from damage of a neurological tissue.
Regenerating a neurological tissue.
Neuroprotection via inhibition of neuronal apoptosis.
Neuroprotection via upregulating Bcl-2.
Neuroregeneration via stimulating axonal re-connections.
Neuroregeneration via stimulating proliferation of endogenous neural progenitor cells.
Modulating neuroinflammation mechanisms including microglial activation and complement activation, including TNF-alpha suppression.
Documented Applications
Protection and/or regeneration of neurological tissue damage in inflammation-associated or neurodegenerative conditions.
COVID-19-associated neurological damage.
Experimental support including microglial cytokine modulation, neuronal apoptosis protection, and proliferation of endogenous neural stem cells under inflammatory conditions.
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