Self-expanding devices and methods therefor
Inventors
Eaton, Donald J. • Huang, Bin • Abbate, Anthony J. • Zaler, Gail M. • Gale, David C.
Assignees
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Publication Number
US-11497835-B2
Publication Date
2022-11-15
Expiration Date
Abstract
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
Core Innovation
The invention provides a method of treating one or more sinus conditions by delivering an expandable device to a paranasal sinus region. The expandable device expands from a first compressed configuration to a second expanded configuration for conformation against sinus tissue, and is configured to release a drug during treatment in the sinus region.
The expandable device includes at least two filaments of a biodegradable polymer. The filaments are formed into a repeating diamond-shaped pattern extending about a circumference of the expandable device, with each diamond extending from a first end of the expandable device to a second end. This geometric filament arrangement is part of the device that expands to conform against sinus tissue.
The documented embodiments further describe self-expanding, biodegradable, filament-based delivery and implant devices configured for placement in sinus cavities, including sinus-specific embodiments. The delivery system includes a cannula for deployment into paranasal sinus regions, and the expanded device includes a lumen in an expanded configuration. The devices can include drug-eluting or drug-depot capabilities, including mometasone furoate, with controlled release profiles.
Claims Coverage
The independent claim covers a sinus-treatment method using a drug-releasing expandable device with biodegradable-polymer filaments arranged in a repeating diamond-shaped circumferential pattern that expands from a compressed configuration to conform against sinus tissue. No additional independent inventive features beyond those recited in the single independent claim are provided in the provided claim excerpt.
Sinus treatment by expandable drug-releasing device conforming to sinus tissue
A method of treating one or more sinus conditions by delivering an expandable device to a paranasal sinus region, wherein the expandable device expands from a first compressed configuration to a second expanded configuration for conformation against sinus tissue, and wherein the expandable device is configured to release a drug.
Biodegradable-polymer filament repeating diamond-shaped circumferential pattern
The expandable device comprises at least two filaments of a biodegradable polymer, wherein the filaments are formed into a repeating diamond-shaped pattern extending about a circumference of the expandable device with each diamond of the repeating diamond-shaped pattern extending from a first end of the expandable device to a second end of the expandable device.
Overall claim coverage centers on the combination of delivery of an expandable device to a paranasal sinus region that conformally expands to sinus tissue and a biodegradable-polymer filament geometry defined by a repeating circumferential diamond-shaped pattern, together with drug release from the expandable device. Dependent refinements in the provided excerpt further specify drug-release timing and duration, drug dosage constraints, polymer material inclusion, and particular sinus cavity selections, as well as optional adjunct anti-infection agent release.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Delivering an expandable, drug-releasing device into a paranasal sinus region for treating one or more sinus conditions.
Delivery device deployment into sinus cavities including ethmoid sinus cavity and maxillary sinus cavity, including delivery to or involving the osteomeatal complex and sinus access context described in the document.
Use of the described drug-eluting/depot expandable filament devices for controlled release of mometasone furoate in vitro and in vivo release contexts described in the document.
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