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Publication Number
US-11491225-B2
Publication Date
2022-11-08
Expiration Date
Abstract
Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.
Core Innovation
The invention relates to a method for impeding lactic acidosis in an individual by administering a topical formulation for transdermal delivery of an active agent comprising sodium bicarbonate. The formulation is defined by a penetrant system that provides lecithin at 5%-15% w/w and sodium bicarbonate at 20%-40% w/w, together with poloxamer 407 at 1%-15% w/w and isopropyl palmitate.
The invention centers on a topical transdermal penetrant/formulation composition in which specific excipients are used together with sodium bicarbonate to impede lactic acidosis. In some implementations, benzyl alcohol is present at 0.5%-20% w/w, propylene glycol is present at about 1%-5% w/w, and sodium lauryl sulfate is present at 0.5%-2.5% w/w.
In dependent aspects, the method includes applying the topical formulation to the individual’s skin and is associated with absorption 10-15 minutes after administering the topical formulation. The method is further associated with increased athletic performance and optional ingredients listed as performance- or nutrition-related compounds.
Claims Coverage
The document provides two independent claims, both directed to methods for impeding lactic acidosis using a transdermal topical formulation containing sodium bicarbonate and a defined lecithin-based penetrant system with poloxamer 407 and isopropyl palmitate, with one claim further specifying additional excipient options.
Topical transdermal sodium bicarbonate method to impede lactic acidosis with defined penetrant system
A method for impeding lactic acidosis in an individual, comprising administering a topical formulation for transdermal delivery of an active agent comprising sodium bicarbonate, wherein the formulation comprises a penetrant that provides lecithin at 5%-15% w/w of the formulation, sodium bicarbonate at 20%-40% w/w of the formulation, a poloxamer 407 at 1%-15% w/w of the formulation, and an isopropyl palmitate.
Topical transdermal sodium bicarbonate method with specified penetrant/excipient set for impeding lactic acidosis
A method for impeding lactic acidosis in an individual, comprising administering a topical formulation for transdermal delivery of an active agent comprising sodium bicarbonate, wherein the formulation comprises a penetrant that provides lecithin at 5%-15% w/w and sodium bicarbonate at 20%-40% w/w, and wherein the formulation comprises one or more of an isopropyl palmitate, benzyl alcohol at 0.5%-20% w/w, propylene glycol at about 1%-5% w/w, poloxamer 407 at 1%-15% w/w, and sodium lauryl sulfate at 0.5%-2.5% w/w.
Across both independent claims, the core claimed coverage is a transdermal topical formulation for impeding lactic acidosis in an individual, where sodium bicarbonate is the active agent and the formulation includes a lecithin-based penetrant system with poloxamer 407 and isopropyl palmitate, with one independent claim further specifying additional excipient ranges.
Stated Advantages
Impedes lactic acidosis in an individual.
Increases athletic performance by up to 64%.
Documented Applications
Impeding lactic acidosis in an individual associated with athletic performance.
Administration is described for an individual prior to muscle exertion (athletic context).
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