Systems and methods for hematocrit impedance measurement using difference identity phase

Inventors

Leone, Steven V.

Assignees

Trividia Health Inc

Abstract

The present disclosure provides a system for measuring a property of a sample comprising: a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a difference identity to generate a sinusoidal signal with an amplitude proportional to the phase difference; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.

Core Innovation

The invention relates to measuring a concentration of an analyte in a sample using a test strip and a diagnostic measuring device, and correcting the analyte measurement due to one or more interferents. The correction is performed by a processor executing an analyte correction that uses an interferent impedance measurement including both a magnitude measurement and a phase measurement.

For the interferent phase measurement, the invention uses a difference identity to generate a sinusoidal signal with an amplitude proportional to a phase difference. The sinusoidal signal represents the phase difference such that the processor can process a signal sufficient for processing by a processor, where the signal represents the phase angle.

After calculating the interferent impedance measurement using the magnitude measurement and the phase measurement derived from the difference identity, the processor adjusts the measurement of the analyte in the sample using the calculated interferent impedance measurement. In dependent forms, the interferent may include hematocrit and the analyte may include glucose, and a temperature correction may be applied to the interferent impedance measurement.

Claims Coverage

The independent claims cover a system and a method that measure an analyte concentration and perform interferent-based analyte correction using interferent impedance measurements with both magnitude and phase. Across the independent claims, three main inventive feature groups appear: interferent impedance magnitude plus phase measurement using a difference identity to generate a phase-difference sinusoidal signal, and adjusting the analyte measurement using the calculated interferent impedance. Additional independent-claim scope differs by whether the claim includes a test strip and diagnostic device structure, but the core correction computation is shared.

The independent claims consistently require correcting an analyte measurement due to one or more interferents by calculating an interferent impedance measurement that includes magnitude and phase. The phase measurement is generated using a difference identity to produce a sinusoidal signal with amplitude proportional to a phase difference, and the resulting calculated interferent impedance is used to adjust the analyte measurement.

Stated Advantages

Documented Applications

No documented applications found