Method for producing a drug delivery system
Inventors
Schneeberger, Achim • Kühne, Klaus • KERSCHBAUMER, Helmut • VASIC, Srdan
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-11484504-B2
Publication Date
2022-11-01
Expiration Date
Abstract
The present invention relates to a method for producing a drug delivery system. The method comprises the steps of screen-printing a base paste, and curing the base paste. Furthermore, the method comprises the steps of screen-printing a first paste separate to the base paste, and curing the first paste.
Core Innovation
The invention relates to a method for producing a drug delivery system by screen-printing and curing a base paste and a separately screen-printed first paste. The base paste and the first paste are soluble in body fluids so that the resulting drug delivery system is soluble in body fluids. The first paste comprises a therapeutically effective amount of a first active pharmaceutical ingredient, API, and is cured separately from the base paste.
The method requires screen-printing the pastes such that in the resulting drug delivery system the first paste is inhomogeneously arranged in the base paste. The base component is provided as a three-dimensional body and the separate first component is inhomogeneously arranged throughout the base component along the three dimensions. As a result, the concentration of the first API varies throughout the drug delivery system.
The concentration profile of the first API is configured so that upon application of the drug delivery system the release of the first API occurs at a varying rate. The method includes a limitation that the first API is not selected from a provided list of APIs. The described arrangement enables tailoring of a varying-rate release based on an inhomogeneous, three-dimensional concentration profile.
Claims Coverage
Independent claim covers 4 inventive features.
Curing a body-fluid-soluble base paste and a separately cured inhomogeneously arranged first paste
A method comprising screen-printing a base paste and curing the base paste, screen-printing a first paste separate to the base paste and curing the first paste, wherein the first paste comprises a therapeutically effective amount of a first API and the base paste and the first paste are soluble in body fluids.
Three-dimensional inhomogeneous arrangement and varying API concentration profile
Screen-printing the pastes such that in the resulting drug delivery system the first paste is inhomogeneously arranged in the base paste, wherein the base component is provided as a three-dimensional body and the separate first component is inhomogeneously arranged throughout the base component along the three dimensions, wherein the concentration of the first API varies throughout the drug delivery system.
Varying-rate first API release upon application from the concentration profile
The concentration profile of the first API is such that upon application of the drug delivery system the release of the first API occurs at a varying rate.
Exclusion of specified first api list
The first API is not selected from a list comprising anthelmintic agents, narcotics and narcotic antagonists, anti-histamines, adrenergic agents, adrenergic blockers, sedative hypnotics, CNS agents, analeptics, antiparkinson agents, steroids, coronary vasodilators, anticoagulants, antihypercholesterolemics, antibiotics, antifungal agents, antiviral agents, anticancer agents, antiinflammatory agents, antihypertensive agents, Pregabalin, Lurasidon, Fentanyl, Rivaroxaban, Sildenafil/Tadalafil, Desatinib, Sorafenib, Varenicline, Memantine, Sunitinib, Nebivolol, Zolmitriptan, Lacosamid, Desvenlafaxin, Lenalidomid, Ledipasvir/Sofosbuvir, Aripiprazole, or Levodopa.
The claim coverage centers on screen-printing and curing a body-fluid-soluble drug delivery system with a separately cured first paste in a three-dimensional inhomogeneous arrangement, producing a varying API concentration profile and varying-rate release upon application, with exclusion of a specified list of first APIs.
Stated Advantages
Enables release of the first API at a varying rate upon application, based on a varying concentration profile created by an inhomogeneous three-dimensional arrangement.
Resulting drug delivery system is soluble in body fluids due to the base paste and first paste being soluble in body fluids.
Documented Applications
Drug delivery upon application of the drug delivery system to achieve release of the first API at a varying rate.
Interested in licensing this patent?