Adhesive device
Inventors
Wang, David Jonq • Mault, James R. • Drake, Eleanor • LEUNG, Henry WeiKang • RO, Brian Chris
Assignees
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Publication Number
US-11484265-B2
Publication Date
2022-11-01
Expiration Date
Abstract
An adhesive device may include a first adhesive surface configured to be adhered to skin of a user, and a second adhesive surface opposite the first adhesive surface and configured to be adhered to a medical device. The adhesive device may also include an intermediate region between the first adhesive surface and the second adhesive surface, where the intermediate region includes a detector compound embedded in the intermediate region configured to change based on interaction of the detector compound with a target molecule.
Core Innovation
The disclosed invention relates to an adhesive device and a system that adhere a low-profile monitoring medical device to skin of a user for extended wear. The adhesive includes one or more layers of material with a first adhesive surface configured to be adhered to skin and a second adhesive surface opposite the first and configured to be adhered to the medical device, with an intermediate region included between these surfaces.
The intermediate region includes a detector compound embedded in the one or more layers of material and configured to change based on interaction of the detector compound with a target molecule. The documented target molecule interactions are tied to sensing sweat/byproducts, including nicotine/cotinine, alcohol and acetate/acetaldehyde, cannabis metabolites, and cocaine byproducts, and readouts include detector change via interaction with electromagnetic radiation, such as visible color of reflected light under multi-wavelength light.
Additional embodiments describe adhesive film moisture transport using one-way moisture permeability and oxygen passage, and a moisture-wicking pocket and optional sensor-aligned cutouts or voids. Other embodiments describe multi-detector or multi-layer detector localization, and an adhesive that retains skin/sweat for third-party spectral analysis or DNA sequencing, including preservation media and stabilizing/lysing agents for retained samples.
Claims Coverage
Across the independent claims, the coverage centers on a layered adhesive structure with a skin-facing adhesive surface, a device-facing adhesive surface, and an intermediate region embedding a detector compound that changes upon interaction with a target molecule. The independent claims also support electromagnetic-radiation-based readout and, in the system claim, detection of the detector-compound change by a sensor of the medical device, plus sweat-related byproduct targets and retention for DNA sequencing.
Layered adhesive with skin-facing and device-facing adhesive surfaces
The adhesive device includes one or more layers of material, including a first adhesive surface configured to be adhered to skin of a user and a second adhesive surface opposite the first adhesive surface and configured to be adhered to a medical device.
Intermediate region embedding a detector compound configured to change on target interaction
The adhesive device includes an intermediate region of the one or more layers of material between the first adhesive surface and the second adhesive surface, the intermediate region including a detector compound embedded in the one or more layers of material and configured to change based on interaction of the detector compound with a target molecule.
Skin-worn system with medical device and adhesive embedding a detector compound
A system comprising a medical device configured to be worn on skin of a user, and an adhesive configured to adhere the medical device to the skin of the user, including one or more layers of material with a first adhesive surface for skin, a second adhesive surface for the medical device, and an intermediate region between the first and second adhesive surfaces that includes a detector compound embedded in the one or more layers of material.
Detector compound change based on interaction with a target molecule in a skin-worn system
In the system, the detector compound is configured to change based on interaction of the detector compound with a target molecule.
Adhesive for adhering a medical device to skin with detector compound embedded in a layer
An adhesive configured to adhere a medical device to skin of a user comprising one or more layers of material, a skin-facing adhesive surface at an outer end, a device-facing adhesive surface at an opposite end, and a detector compound embedded in a first layer, the detector compound configured to change based on interaction with a target molecule.
The independent claim set defines a skin-worn medical monitoring arrangement built around a layered adhesive having skin-facing and device-facing adhesive surfaces, with an intermediate region that embeds a detector compound whose change is triggered by interaction with a target molecule. The claims further support readout narrowing, including electromagnetic radiation interaction such as visible color under multi-wavelength light, system-level sensing by a medical device sensor, and specified sweat-related byproducts and DNA sequencing retention as recited in the claim refinements.
Stated Advantages
Allows a detector compound embedded in an adhesive intermediate region to change based on interaction with a target molecule.
Enables detector change readout via interaction with electromagnetic radiation, including visible color of reflected light under multi-wavelength light.
Enables detector-compound change detection using a sensor of the medical device.
Supports target molecules involving byproducts eluted through sweat for specified drugs.
Enables use of adhesive material that adheres to and retains epithelial tissue, skin, or hair for DNA sequencing.
Documented Applications
Adhering a low-profile monitoring medical device to skin of a user for extended wear.
Sensing sweat-eluted drug-related byproducts, including nicotine/cotinine, alcohol byproducts (acetate/acetaldehyde), cannabis metabolites, and cocaine-related byproducts.
Providing detector-compound readouts using electromagnetic radiation, including visible color under multi-wavelength light.
Retaining skin/sweat for third-party spectral analysis or DNA sequencing, including the use of preservation media and stabilizing/lysing agents for retained samples.
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