Methods, systems, and devices for monitoring anisocoria and asymmetry of pupillary reaction to stimulus
Inventors
Siminou, Kamran • Privitera, Claudio
Assignees
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Publication Number
US-11484197-B2
Publication Date
2022-11-01
Expiration Date
Abstract
A computer program is disclosed for performing the following method: recording images of a response of a left pupil to a stimulus thereby resulting in a first set of sequential images; recording images of a response of a right pupil to the same stimulus at the same time as the first images were recorded, thereby resulting in a second set of sequential images; displaying on a display simultaneously the first set of images and the second set of image, wherein the two sets of images are synchronized, and wherein a center of the left pupil of each image from the first set of sequential images is aligned with a center of the right pupil from the second set of sequential images on the display.
Core Innovation
A pupillometry system and associated method/program assess a health condition of a mammalian subject by monitoring anisocoria and pupillary asymmetry. The approach records images of a response of a left pupil and a right pupil simultaneously and synchronizes the left-pupil response with the right-pupil response. Images and frames from the two eyes are synchronized to enable direct comparison during monitoring.
The disclosed approach uses a pupilometer to compare the response of the left pupil to the response of the right pupil, and to detect anisocoria in the pupillary response. During playback, the system simultaneously displays left- and right-pupil videos with alignment of left and right pupil centers, so that corresponding pupil features are presented in a coordinated manner.
To visually enhance detection of left/right differences, the system provides overlays on the displayed pupil images. The overlays include a straight line through pupil centers, and optionally a set of parallel lines whose spacing corresponds to the left versus right pupil diameters. The overlay uses different colored sections for the left and right diameter-related portions, and anisocoria detection can be based on differences derived from the parallel-line spacing between corresponding sections.
Claims Coverage
The independent claim in family clm-00001 covers a method for assessing a health condition by simultaneously recording synchronized left- and right-pupil responses, using a pupilometer to detect anisocoria, and diagnosing an abnormal health condition when anisocoria is present. Dependent claims refine the method by specifying display synchronization with center alignment and by defining parallel-line overlays whose spacing is tied to left and right pupil diameters, including color distinction, and by using those spacing differences for anisocoria determination.
Simultaneous synchronized recording of left and right pupil responses
recording images of a response of a left pupil and a right pupil of the subject simultaneously, and synchronizing the response of the left pupil with the response of the right pupil
Pupilometer comparison of synchronized left and right pupil responses
using a pupilometer to compare the response of the left pupil to the response of the right pupil wherein the response of the left pupil is synchronized with the response of the right pupil
Anisocoria detection and diagnosis from the pupilometer comparison
using the pupilometer to detect anisocoria in the pupillary response of the subject, and diagnosing the patient with an abnormal health condition in the presence of anisocoria
Synchronized display with aligned pupil centers
displaying synchronized left-pupil and right-pupil image sets on the pupilometer display, wherein the centers of corresponding left and right pupil images are aligned
Parallel-line overlay tied to left and right pupil diameters
drawing parallel lines from the left pupil perimeter to the right pupil perimeter in each image, with the spacing between lines determined by the left pupil diameter in a first section and by the right pupil diameter in a second section
Color-distinguished parallel-line sections
wherein the parallel lines in the first section have a different color than the parallel lines in the second section
Anisocoria detection based on parallel-line distance differences
detecting anisocoria by determining the difference in sizes of two pupils, based on differences in distances between parallel lines in a first section and parallel lines in a second section
Across the independent claim, anisocoria assessment is grounded in simultaneous recording and synchronization of left/right pupil responses, pupilometer-based comparison, anisocoria detection, and diagnosis when anisocoria is present. Dependent refinements further constrain presentation and measurement by synchronized left/right display with aligned centers and by parallel-line overlays whose spacing and color-separated sections are tied to left and right pupil diameters, enabling anisocoria determination from the spacing differences across sections.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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