Disinfectants with iodine and copper complexes for use against coronavirus
Inventors
Morgan, Douglas J. • Harrison, Steve • Rhodes, Tanya
Assignees
Clyra Medical Technologies • Clyra Medical Technologies Inc
Publication Number
US-11457632-B1
Publication Date
2022-10-04
Expiration Date
2040-05-14
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Abstract
Liquid antimicrobial disinfectant compositions for treatment of coronaviruses and specifically the Covid-19 virus (SARS-CoV-2) on skin and surfaces such as PPE (personal protective equipment) are disclosed that are highly efficacious and exhibit total eradication below detectable limits at 30 minutes (>6 log kill) against coronavirus (resulting in complete inactivation), while remaining non-toxic, safe and non-irritating (including at a cellular level and with extended contact) to skin and endogenous tissue. Such disinfectant compositions are additionally highly effective against other pathogens, have extended antimicrobial and antiviral activity for more than 24 hours, have a bio-compatible pH, are suitable for personal, clinical and surgical use and are safe to skin, mucous membranes and wounds, remain stable without precipitation, discoloration or loss of antimicrobial efficacy for at least 12 months, and are beneficial for a range of applications and uses in improving and supporting human and animal health.
Core Innovation
The invention disclosed is a stable antimicrobial disinfectant composition comprising a mixture of potassium iodide and copper sulfate in a carrier liquid such as water or saline. The composition generates an amount of free iodine between about 100 ppm and about 330 ppm, typically about 250 ppm, and maintains a biologically acceptable pH ranging from about 3.5 to about 7.5, often from about 4.5 to about 6.0. It is designed to be non-toxic, safe, and non-irritating (including at a cellular level and with extended contact) to endogenous tissue and skin. The formulation is free of buffers, acidifying agents, surfactants, and peptides, and remains stable without precipitation or discoloration for at least 12 months, with some embodiments achieving stability for up to 24 months.
The composition demonstrates highly effective antimicrobial activity for 24 hours or more with a greater than 4 log kill rate against common pathogens, including the noxious nosocomial ESKAPE pathogens, and total eradication below detectable limits within 30 minutes (>6 log kill) against coronaviruses such as SARS-CoV-2. Its efficacy extends to mature biofilms where it achieves log reduction superior to current standards. Additionally, it affords sustained antimicrobial activity for multiple days and can be safely applied directly to skin, wounds, mucous membranes, and personal protective equipment (PPE). The unique balance between potassium iodide and copper sulfate produces free iodine and copper complexes that provide this effectiveness while avoiding the cytotoxicity and wound healing delays commonly associated with prior iodine-based products.
Claims Coverage
The patent includes one independent claim focusing on the method of providing the stable antimicrobial disinfectant solution against coronavirus with specified components and properties. The main inventive features are extracted as follows.
Composition formulation with specific concentrations and components
The method involves providing a carrier liquid comprising water or saline that makes up about 95% to 99.9% of the solution by weight. Potassium iodide is added at a first effective concentration and copper sulfate at a second effective concentration such that their mixture generates free iodine from about 100 ppm to 330 ppm without any metallo-peptides, acidifying agents, buffers, or surfactants.
Maintaining pH and stability without discoloration or precipitation
The solution maintains a pH from about 4.0 to 7.0 without discoloration or solid iodine precipitation for at least 6 months, with embodiments extending stability to at least 12 or 24 months.
Specific ratios and concentrations of reagents
The ratio of moles of potassium iodide to copper sulfate is maintained from about 1.25 to 1.75. Effective concentrations include potassium iodide and copper sulfate pentahydrate both ranging approximately from 0.025% to 0.100% by weight, with a preferred embodiment around 0.0625% each.
Efficacy against human coronaviruses including SARS-CoV-2
The solution exhibits total eradication below detectable limits within 30 minutes (>6 log kill) against human coronaviruses such as HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2 or mutated strains thereof.
Prolonged antimicrobial activity
The solution maintains effective antimicrobial activity for at least three days, supporting sustained antimicrobial and antiviral effects.
Overall, the independent claim details a composition and method of preparation with a unique combination of potassium iodide and copper sulfate in a carrier liquid, maintaining free iodine concentrations, pH stability, and providing potent antimicrobial and antiviral activity, particularly against coronaviruses, while being non-toxic and stable for extended periods.
Stated Advantages
The composition is highly efficacious against coronaviruses, achieving total eradication below detectable limits within 30 minutes (>6 log kill), including SARS-CoV-2.
It exhibits sustained antimicrobial and antiviral activity for 24 hours or more with a greater than 4 log kill rate against common pathogens, including the ESKAPE pathogens.
The disinfectant composition is non-toxic, safe, and non-irritating to human skin and endogenous tissue, including under prolonged contact.
It maintains a biocompatible pH suitable for direct application on or within the body or wounds, avoiding pain, irritation, or harmful effects.
The solution remains stable without precipitation, discoloration, or loss of antimicrobial efficacy for at least 12 to 24 months.
It can be safely used repeatedly on personal protective equipment (PPE) and skin without causing drying, cracking, or residue, unlike high-alcohol hand sanitizers.
The composition effectively reduces biofilm, exceeding the reduction standards of current medical antiseptics like Povidone Iodine.
Documented Applications
Treatment of wounds and burns including chronic, pathological, traumatic, and surgical wounds and ulcers.
Prevention and treatment of infections caused by bacterial, viral, fungal, and parasitic pathogens on skin and in wounds.
Use as a disinfectant for personal protective equipment (PPE), gloves, masks, and surfaces to eliminate coronaviruses including SARS-CoV-2.
Application as an oral rinse or wash to reduce oral bacterial load during dental and surgical procedures.
Use in hospital-grade disinfection for skin and surfaces and prophylactic or therapeutic treatment in surgical sites.
Use on animals for wound treatment, infection prevention, or as a disinfectant and oral rinse.
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