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Publication Number
US-11457631-B2
Publication Date
2022-10-04
Expiration Date
Abstract
Organophosphorus or organosulfur compounds and methods of using the compounds as cleaning agents, particle dispersants, or surfactants, or to remove, disperse or inhibit the growth of a biofilm, or inhibit the growth of, or kill a fungus or bacteria are provided.
Core Innovation
The disclosure relates to compounds of Formula I, or salts thereof, including compounds represented by Formula II and Formula III, with substituent-variable definitions for A, X, Y, G, R1, R2, R3, and R4. The compounds are described by structural frameworks including organophosphorus and organosulfur chemical scaffolds, phosphonate/phosphoric-acid-containing motif-containing candidate compounds, and an S-linked backbone in Formula III.
The compounds and compositions are described as cleaning and decontaminating agents for surfaces, and as cleaning agents and dispersants/surfactants. They are further described as particle dispersants, with dispersant activity, and with antibiofilm and antifouling activity.
The disclosure also states antimicrobial and antifungal activity, including inhibiting growth or killing fungi or bacteria and activity directed to biofilm, fungi, and bacteria. Embodiments are described for contacting or applying the compounds on biofilms, fungi, bacteria, living tissue, and non-living surfaces including medical devices, marine vessels, industrial equipment, surface coatings/paints, and soaps/detergents.
Claims Coverage
The independent claim coverage centers on structurally defined Formula I compounds, or salts thereof, and on methods that contact biofilms, fungi, bacteria, or surfaces with an effective amount. Across the family, the main inventive features are the Formula I scaffold with defined substituent sets and the functional use as cleaning, dispersant/surfactant, antibiofilm/antifouling, antimicrobial, and anti-fungal agents.
Formula I compound with defined substituents
A compound of Formula I, or a salt thereof, wherein A is C1-10 hydrocarbyl or optionally R1-substituted C1-10 hydrocarbyl; X is —NHR, —NHOR, —NHCOR, or —NHOCOR; R is H; and R1, R2, R3, and R4 are selected from the enumerated groups and optional substitution sets, including phosphonic acid and phosphonic acid-containing options.
Contacting biofilms, fungi, or bacteria with an effective amount of Formula I
A method that disperses or inhibits biofilm growth and inhibits growth or kills fungi or bacteria by contacting them with an effective amount of a Formula I compound or a composition containing that amount.
Treating a surface to provide functional surface-agent roles
A method for treating a surface by contacting it with an effective amount of a Formula I compound so the compound functions as one or more surface-treatment agent types including cleaning, dispersing, surfactant, biofilm removal/antibiofilm, antifouling, antimicrobial, or anti-fungal activity.
Compositions comprising the Formula I compound
A composition that includes the compound recited in claim 1.
The claim set is anchored on a structurally defined Formula I compound, or salt thereof, with explicit variability for A, X, R1, R2, R3, and R4. The use coverage includes contacting biofilms, fungi, or bacteria with an effective amount and treating surfaces to achieve cleaning, dispersing/surfactant, antibiofilm, antifouling, antimicrobial, and anti-fungal functions.
Stated Advantages
Cleaning and decontaminating surfaces.
Cleaning agent function.
Dispersant/surfactant function.
Dispersant activity.
Dispersing or removing biofilm.
Inhibiting biofilm growth.
Anti-biofilm and biofilm dispersal/removal functionality.
Antifouling functionality.
Antibiofilm and antifouling activity.
Antimicrobial activity against bacteria.
Antifungal activity against fungi.
Inhibiting growth of fungi or bacteria and killing fungi or bacteria.
Functional roles as a particle dispersant and surfactant for the treated surfaces.
Documented Applications
Cleaning and decontaminating surfaces using compounds of Formula I (and salts/compositions).
Cleaning and dispersant/surfactant use of Formula I/II/III compounds.
Dispersing or inhibiting biofilm growth by contacting biofilms with an effective amount of a Formula I compound or composition.
Treating surfaces by contacting them with an effective amount of a Formula I compound so it functions as cleaning, dispersing, surfactant, biofilm removal/antibiofilm, antifouling, antimicrobial, and/or anti-fungal.
Application as antibiofilm and antifouling agents to address biofilm and fouling.
Use as antimicrobial and antifungal agents by contacting with effective amounts.
Applying the compounds on living tissue and on non-living equipment surfaces including medical devices, marine vessels, and industrial equipment.
Surface treatment by contacting surfaces with effective amounts, including surface coatings/paints and soaps/detergents.
Use on indwelling medical devices for activity associated with biofilm and fouling control.
Industrial/marine systems applications directed to fouling.
Inhibiting growth of, or killing, fungi or bacteria by contacting them with an effective amount of a Formula I compound or composition.
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