Applicator for water-soluble sheet-shaped preparation
Inventors
Quan, Ying-shu • Li, Ying-zhe • Higuchi, Kiyotsune • Tanaka, Hiroshi • Kamiyama, Fumio
Assignees
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Publication Number
US-11452852-B2
Publication Date
2022-09-27
Expiration Date
Abstract
A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation which is composed of a liquid container and the nozzle.
Core Innovation
The invention relates to a nozzle having at least one hole on an end portion, wherein the end portion includes a plane capable of holding a sheet-like water-soluble preparation. Concave-convex portions are formed on a portion of the plane excluding the hole, and the depth of the concave-convex portions is 0.1 to 3.0 mm.
The concave-convex portions are described as assisting the preparation on the nozzle and enabling uniform supply of water from the nozzle hole toward the back side of the sheet-like water-soluble preparation. The end plane is structured to support adhesion and detachment behaviors of the sheet-like water-soluble preparation during use.
An applicator is further described as combining the nozzle and a liquid container, enabling liquid supply to the back side of the sheet-like water-soluble preparation. The liquid container is described in different modes including press/penetration, a spray device, and a pump, and the arrangement contributes to rapid dissolution of the microneedle array/patch and improved skin coverage.
Claims Coverage
The document includes one independent claim directed to the nozzle structure and its defined concave-convex portions, with dependent claims refining geometry, orientation, material, and extending to an applicator supplying liquid to the back side of the sheet-like water-soluble preparation. In total, the inventive features concentrate on a nozzle with a hole and concave-convex portions on the end plane excluding the hole, a defined depth range, and applicator liquid-supply modes using a liquid container, spray device, or pump.
Nozzle with hole and concave-convex portions on an end plane excluding the hole
A nozzle having at least one hole on an end portion with a plane sized to hold a sheet-like water-soluble preparation, wherein concave-convex portions are provided on a portion of the plane excluding the hole.
Concave-convex depth range
The depth of the concave-convex portions is 0.1 to 3.0 mm.
Concave-convex portions forming grooves from the hole to a peripheral edge
The concave-convex portions form grooves extending from the hole toward a peripheral edge of the end portion.
Plane orientation relative to hole path
The plane of the end portion is perpendicular to a path formed by the at least one hole.
Nozzle made of selected synthetic resin
The nozzle is made of a synthetic resin selected from a group consisting of a polyethylene resin, a polypropylene resin, a polyurethane resin, a polyvinyl chloride, and a silicone resin.
Applicator with press supplied liquid to the back side
An applicator in which the sheet-like water-soluble preparation is held on the end portion of the nozzle for application to skin, and a liquid is supplied to the back side of the preparation by pressing the liquid container.
Applicator with pump driven liquid ejection to the back side
An applicator in which the sheet-like water-soluble preparation is held on the end portion of the nozzle for application to the skin, and the liquid is ejected to the back side of the preparation by pushing the pump.
Overall claim coverage centers on a nozzle end portion whose plane is sized to hold a sheet-like water-soluble preparation, with concave-convex portions on the plane excluding the hole and having a depth of 0.1 to 3.0 mm, optionally further defined by groove formation and orientation and optionally formed from selected synthetic resins. The dependent claims also extend the concept to an applicator that supplies liquid to the back side of the sheet-like water-soluble preparation by pressing a liquid container or by using a pump.
Stated Advantages
Provides rapid dissolution of the microneedle array/patch, as illustrated by Example 1 dissolution after about 1.5 minutes.
Improves skin coverage.
Improves handling/adhesion and detachment behavior relative to a flat nozzle configuration, as indicated by comparative examples.
Documented Applications
Application of a microneedle array/patch involving a sheet-like water-soluble preparation to skin, where liquid is supplied to the back side of the preparation using the described nozzle and applicator.
Demonstrated dissolution behavior for microneedle array/patch formulations in Example 1 and comparative examples.
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