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Publication Number
US-11452474-B1
Publication Date
2022-09-27
Expiration Date
Abstract
A system includes an applicator and a dermal patch coupled to the applicator. The applicator includes a needle configured to puncture a subject's skin to draw a physiological sample, a first actuating lever configured to move form an undeployed position to a deployed position, and a second actuating lever configured to move form an undeployed position to a deployed position. The dermal patch includes a fluid reservoir configured to store a processing fluid, a sample collection chamber configured to receive the processing fluid and the physiological sample, wherein the applicator is configured to cause the needle to puncture the subject's skin to draw the physiological sample when the first actuating lever is moved from the undeployed lever position to the deployed lever position and cause the processing fluid to release from the fluid reservoir when the second actuating lever is moved from the undeployed position to the deployed position.
Core Innovation
The invention provides a system that includes an applicator with a needle configured to puncture a subject’s skin to draw a physiological sample, and an applicator control structure with a first actuating lever and a second actuating lever. The first and second actuating levers move from undeployed positions to deployed positions, and a latch maintains the second actuating lever in a locked position so as to inhibit movement when the first actuating lever is in the undeployed position.
Upon actuation of the first actuating lever, the latch is released to allow actuation of the second actuating lever. In coordination with the lever positions, the applicator causes the needle to puncture the skin when the first actuating lever moves to the deployed position, and causes processing fluid to be released from a fluid reservoir when the second actuating lever moves to the deployed position.
The system includes a dermal patch configured for coupling to the applicator, with a fluid reservoir storing a processing fluid and a sample collection chamber configured to receive the processing fluid and the physiological sample. In one aspect, the processing fluid processes the physiological sample so that a detector in the dermal patch detects a target analyte in the processed physiological sample resulting from processing by the processing fluid.
The described processing and detection approach supports target analyte detection using a detector configured to detect a target analyte, including embodiments that use isothermal amplification reagents and embodiments that use one of an immunoassay detector, an isothermal amplification detection system, a graphene-based detector, an electrochemical detector, or a chemical detector.
Claims Coverage
The document provides two independent claims. Each independent claim shares the same core mechanical system using an applicator with needle puncturing, first and second actuating levers coordinated by a latch, and a dermal patch that receives released processing fluid and physiological sample; one independent claim further requires a detector that detects a target analyte in a processed physiological sample.
Two-lever needle puncturing and coordinated processing-fluid release
An applicator including a needle configured to puncture a subject's skin to draw a physiological sample; a first actuating lever configured to move from an undeployed position to a deployed position; a second actuating lever configured to move from an undeployed position to a deployed position; and a latch configured to maintain the second actuating lever in a locked position so as to inhibit movement thereof when the first actuating lever is in the undeployed position and configured to be released upon actuation of the first actuating lever so as to allow actuation of the second actuating lever; a dermal patch including a fluid reservoir configured to store a processing fluid and a sample collection chamber configured to receive the processing fluid and the physiological sample, wherein the applicator is configured to cause the needle to puncture the subject's skin to draw the physiological sample when the first actuating lever is moved from the undeployed lever position to the deployed lever position and cause the processing fluid to be released from the fluid reservoir when the second actuating lever is moved from the undeployed position to the deployed position.
Target-analyte detection in processed physiological sample
An applicator including a needle configured to puncture a subject's skin to draw a physiological sample; a first actuating lever configured to move from an undeployed position to a deployed position; a second actuating lever configured to move from an undeployed position to a deployed position; and a latch configured to maintain the second actuating lever in a locked position so as to inhibit movement thereof when the first actuating lever is in the undeployed position and configured to be released upon actuation of the first actuating lever so as to allow actuation of the second actuating lever; and a dermal patch including a fluid reservoir configured to store a processing fluid and a detector configured to detect a target analyte in a processed physiological sample resulting from processing the physiological sample by the processing fluid, wherein the applicator is configured to cause the needle to puncture the subject's skin to draw the physiological sample when the first actuating lever is moved from the undeployed lever position to the deployed lever position and cause the processing fluid to release from the fluid reservoir when the second actuating lever is moved from the undeployed position to the deployed position.
Both independent claims cover an applicator-dermal patch system where a needle punctures skin to draw a physiological sample and where processing fluid is released in a coordinated manner using two actuating levers and a latch. One claim additionally requires a detector that detects a target analyte in a processed physiological sample resulting from processing by the processing fluid.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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