System and method for outcome tracking and analysis
Inventors
Pellini, Michael • Palmer, Gary • Lancelotta, Mary Patricia • Hawryluk, Matthew J. • Miller, Vincent A.
Assignees
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Publication Number
US-11450438-B2
Publication Date
2022-09-20
Expiration Date
Abstract
A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.
Core Innovation
The disclosed cancer outcome-tracking system organizes treatment and outcome records indexed by genomic-based indices, affected gene or pathway, tumor type, and treatment. A model processes physician-entered updates to a patient's treatment or outcome, dynamically identifies a set of similar patients, and configures user interfaces to present a personalized patient timeline indicating treatments and outcomes associated with the patient.
The user interfaces categorize treatment and outcome information into selectable categories to organize updates, timelines, genomic alteration results, clinical trials, and therapies. The system configures a treatment data structure associated with similar patients and provides a genomic filter to locate treatment and outcome information across tumor types, thereby informing clinical treatment decisions, including off-label uses.
Claims Coverage
The patent provides three independent claims—claim 1 covering a method, claim 27 covering an electronic device, and claim 53 covering a non-transitory computer-readable storage medium—encompassing three inventive features.
Genomic-indexed treatment and outcome tracking method
Independent claim 1 covers generating a model configured to analyze treatment and outcome data by indexing outcome data based on genomic-based indices, receiving and processing patient updates through selectable categories, dynamically identifying similar patients, and configuring interfaces with a personalized timeline and a genomic-filtered treatment data structure for patients with the same or similar genomic alterations in one or more tumor types.
Electronic device for presenting patient treatment and outcome information
Independent claim 27 covers an electronic device comprising a display, processors, and memory storing instructions to perform genomic-indexed outcome modeling, patient update processing, similar-patient identification, and interface configuration presenting personalized timelines and genomic filters to locate treatment and outcome information across tumor types.
Computer-readable storage medium for genomic-indexed treatment information
Independent claim 53 covers a non-transitory computer-readable storage medium storing instructions that cause an electronic device to model treatment and outcome data using genomic-based indices, process patient updates, identify similar patients, and configure interfaces presenting personalized timelines and genomic-filtered treatment data structures.
Together, the independent claims cover method, device, and computer-readable medium implementations of a system that indexes outcome data by genomic information, processes patient updates, dynamically identifies similar patients, and presents personalized timelines and genomic-filtered treatment information to support clinical decision-making.
Stated Advantages
Selectable categories in the user interface minimize the time required by a physician to input patient treatment and outcome information.
The treatment data structure associated with similar patients provides actionable or advisory information for treatment decision-making.
The genomic-filtered interface allows physicians to locate treatment and outcome information for patients with the same or similar genomic alterations across tumor types to inform decisions regarding off-label uses of a treatment.
Documented Applications
Tracking cancer treatment and outcome information through patient updates, outcomes, and personalized patient-history timelines.
Locating and reviewing treatment and outcome information for similar patients with the same or similar genomic alterations across one or more tumor types to inform treatment decisions, including off-label uses.
Presenting genomic alteration-associated interpretations, therapies, clinical trials, references, updates, dynamic displays, and static patient reports to support clinical decision-making.
Providing community pages or portals for access to anonymized case studies, clinical trials, and genomic knowledge-base searches.
Generating a prostate cancer patient report that links detected genomic amplifications to treatment implications and potentially relevant clinical trials.
Displaying treatment information for patients with colorectal tumors and a BRAF V600E alteration, with outcome-data links for treatments including vandetanib, erlotinib, and everolimus.
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