Transdermal permeant application device
Inventors
Roux, Serge • Kadamus, Christopher • MESSIER, Bernadette C. • Kascak, Uros • BARR, Nathan
Assignees
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Publication Number
US-11446478-B2
Publication Date
2022-09-20
Expiration Date
Abstract
The device of the present invention comprises an intervening release liner as a common special feature, and the intervening release liner covers a part of an adhesive surface of a patch. The intervening release liner gets away from the patch, and is fixed to a patch application support (or porator tab). Due to such constitution, under a situation in use where the first part of the adhesive area of the patch adheres to a skin surface, the patch application support is slidable along the skin surface while peeling the intervening release liner from said part of the adhesive area of the patch to adhere to the skin surface.
Core Innovation
A transdermal permeant application device is provided with a patch application support, a patch having an adhesive area with a first part and a second part, and an intervening release liner provided between the patch application support and the patch. The intervening release liner covers the second part of the adhesive area and is fixed to the patch application support, and a porating element is provided in or on the patch application support and is adapted to form at least one pore in a skin surface.
In use, the first part of the adhesive area adheres to the skin surface and the porating element forms the at least one pore in the skin surface. The patch application support is slidable along the skin surface and peels the intervening release liner from the second part of the adhesive area of the patch, so the second part adheres to the skin surface and the patch alignedly covers the porated area.
In further embodiments, the patch application support comprises a porator backing and a porator tab, where the porator tab is a band-shaped plate with an objective-surface facing outwardly to contact the skin surface and a back-surface opposite the objective-surface. The porator tab includes one or more filaments as the porating element in a porating area in the objective-surface, configured to generate heat to form the at least one pore, including one or more micropores, and the patch is positioned on the back-surface with a reservoir releasably containing a permeant and alignedly positioned corresponding to the porating area.
To support positional control, a fork is provided to hold the patch at a given position in relation to the patch application support. The fork comprises two claws fitted in the patch application support and a flat part under which an upper side of the first part of the adhesive area is attached directly or via a casting sheet, and the reservoir delivers permeant through or into the at least one pore.
Claims Coverage
The provided material contains three independent claims. Across the independent claims, the coverage centers on a slidable patch application support that peels an intervening release liner from a second adhesive part after pore formation, enabling aligned coverage of a porated skin area. The claims also add a reservoir positioned to deliver permeant to the pore(s), a fork mechanism to hold the patch at a given position, and a porator tab with filaments generating heat to form pores including micropores.
Slidable patch application support for peeling intervening release liner and aligned pore area coverage
A transdermal permeant application device with a patch application support; a patch having an adhesive area including a first part and a second part; and an intervening release liner between the patch application support and the patch that covers the second part of the adhesive area and is fixed to the patch application support; a porating element provided in or on the patch application support and adapted to form at least one pore in a skin surface; and wherein in use the patch application support with the porating element is slidable along the skin surface to peel the intervening release liner from the second part of the adhesive area of the patch to adhere the second part to the skin surface and allow the patch to alignedly cover the porated area.
Heat-generating filament porator tab with aligned reservoir delivering permeant through pore(s)
A transdermal permeant application device comprising a porating element provided in or on the patch application support and adapted to form at least one pore in a skin surface; a porator backing; and a porator tab as the patch application support, the porator tab being a band-shaped plate with one end fixed to the porator backing, the porator tab including an objective-surface contacting the skin surface in use, a back-surface opposite the objective-surface, and one or more filaments as the porating element in a porating area in the objective-surface configured to generate heat to form the at least one pore, wherein the at least one pore comprises one or more micropores; wherein the patch application support with the porating element is slidable along the skin surface to peel the intervening release liner from the second part of the adhesive area to adhere the second part and allow the patch to alignedly cover the porated area; and wherein the patch is positioned on the back-surface opposite the objective-surface with a reservoir releasably containing a permeant alignedly positioned corresponding to the porating area with the adhesive surface facing the skin of the subject.
Fork holding the patch at a given position during slidable peeling aligned coverage
A transdermal permeant application device comprising a patch application support; a patch having an adhesive area including a first part and a second part; and an intervening release liner provided between the patch application support and the patch that covers the second part of the adhesive area and is fixed to the patch application support; a porating element adapted to form at least one pore in a skin surface; a fork to hold the patch at a given position in relation to the patch application support, the fork comprising two claws fitted in the patch application support and a flat part under which an upper side of the first part of the adhesive area is attached directly or via a casting sheet; a porator backing with the patch application support; and wherein the patch application support comprises an objective-surface contacting the skin surface of a subject and one or more filaments configured to generate heat to form the at least one pore in the skin, wherein the at least one pore comprises one or more micropores; and wherein in use with the first part adhering and the porating element forming the pore(s), the patch application support is slidable along the skin surface to peel the intervening release liner from the second part to adhere the second part to the skin surface and allow the patch to alignedly cover the porated area.
Across the independent claims, the central inventive concept is the combination of forming at least one pore in a skin surface by a porating element on or in a patch application support, and using that same patch application support to slide and peel an intervening release liner from a second adhesive part after the first adhesive part is already adhered to the skin. The independent claims further specify pore formation using heat-generating one or more filaments, align a permeant reservoir with the porating area, and include a fork with two claws and a flat part to hold the patch at a given position relative to the patch application support.
Stated Advantages
Fewer user steps.
Improved alignment accuracy and repeatability.
Immediate adhesion after poration.
Reduced user mis-handling risks.
Documented Applications
Transdermal permeant delivery to skin using a permeant reservoir patch aligned over a porated area formed by a porating element.
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