Systems, devices, and methods for electromechanical sensing and mapping
Inventors
Assignees
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Publication Number
US-11433243-B2
Publication Date
2022-09-06
Expiration Date
Abstract
Systems, devices, and methods for tracking and determining the motion of a cardiac implant is disclosed. The motion of the implant is determined by transmitting acoustic energy to a tissue location using an acoustic controller-transmitter comprising an array of acoustic transducers; wherein the implant is configured to convert the transmitted acoustic energy to electrical energy; and the tracking is achieved by determining the electrical energy delivered to the tissue throughout one or more cardiac cycles in order to create a motion profile of the cardiac implant.
Core Innovation
The invention provides an implantable acoustic controller-transmitter comprising an array of acoustic transducers that transmit acoustic energy to a location of cardiac tissue, together with at least one implantable acoustic receiver adapted to receive acoustic energy and convert the acoustic energy into electrical energy delivered to the cardiac tissue. The system measures the delivered electrical energy to determine a location of the receiver, tracks the location of the receiver through one or more cardiac cycles to create a motion profile of the receiver relative to the cardiac tissue, and maps a cardiac motion based on the motion profile.
A central capability is dynamic tracking using delivered electrical energy signals across cardiac cycles, where detection of delivered electrical energy enables tracking of three-dimensional (3D) motion data of the implantable acoustic receiver and mapping of cardiac tissue location based on that 3D motion data. The motion profile is normalized with EKG data and correlated with EGM data to create electromechanical motion profiles, linking mechanical behavior to electrical signals measured at or related to the cardiac tissue location.
The disclosed mapping and motion tracking can be used to determine pacing timing and/or location by using a motion profile and/or electromechanical motion profile, including pacing stimulation based on end-diastolic position or motion persistence, and correlating electromechanical motion with EGM characteristics across cardiac phases.
Additional disclosed aspects include implantable motion mapping by detecting delivered electrical energy continuously throughout one or more cardiac cycles, creating an electromechanical map by correlating EGM data and 3D motion data, and correlating motion magnitude with changes in ejection fraction. In at least one approach, mechanical delay is measured during intrinsic conduction and changes in mechanical delay are determined in response to electrical stimulation of the left ventricle, electrical stimulation of the right ventricle, and/or intrinsic conduction.
Claims Coverage
The provided independent claims cover a core framework of implantable acoustic energy delivery paired with electrical-energy-based receiver tracking to create motion profiles and electromechanical maps, with optional normalization/correlation with EKG/EGM and downstream uses. Across the independent claims, the inventive features include device/system structure for acoustic controller-transmitter and acoustic receiver-converter, delivered electrical-energy detection for dynamic 3D tracking, mapping of cardiac motion/location, and correlation/normalization to generate electromechanical motion profiles and maps.
Acoustic controller-transmitter with receiver-to-tissue electrical energy for location tracking and cardiac motion mapping
An implantable acoustic controller-transmitter comprises an array of acoustic transducers configured to transmit acoustic energy to a location of cardiac tissue; an implantable acoustic receiver receives acoustic energy and converts it into electrical energy delivered to the cardiac tissue; the system measures the delivered electrical energy to determine a location of the receiver, tracks the location of the receiver through one or more cardiac cycles to create a motion profile of the receiver relative to the cardiac tissue, and maps a cardiac motion based on the motion profile.
Location-normalized acoustic receiver motion profiling with EKG
A method includes transmitting acoustic energy to a location of cardiac tissue using an implantable acoustic controller-transmitter comprising an array of acoustic transducers; converting the transmitted acoustic energy to electrical energy using an acoustic receiver-converter; delivering the electrical energy to the cardiac tissue; tracking the location of the receiver-converter throughout one or more cardiac cycles; creating a motion profile of the receiver-converter; and normalizing the motion profile with EKG data.
Electromechanical motion profile creation by correlating motion profile with EGM data
A method includes transmitting acoustic energy to a location of cardiac tissue using an implantable acoustic controller-transmitter comprising an array of acoustic transducers; converting the transmitted acoustic energy to electrical energy using an acoustic receiver-converter; delivering the electrical energy to the cardiac tissue; tracking the location of the receiver-converter throughout one or more cardiac cycles; creating a motion profile of the receiver-converter; and correlating the motion profile with EGM data to create an electromechanical motion profile.
Dynamic 3D motion tracking from delivered electrical energy and mapping cardiac tissue location
An implantable acoustic controller-transmitter comprises an array of acoustic transducers configured to transmit acoustic energy to a location of cardiac tissue; at least one implantable acoustic receiver receives at least a portion of the acoustic energy, converts the acoustic energy into electrical energy, and delivers the electrical energy to the cardiac tissue; the system detects the delivered electrical energy throughout one or more cardiac cycles to dynamically track three-dimensional (3D) motion data of the implantable acoustic receiver, and maps the cardiac tissue location based on the 3D motion data.
Electromechanical mapping by combining 3D motion data with EGM data
An implantable acoustic controller-transmitter comprises an array of acoustic transducers configured to transmit acoustic energy to a cardiac tissue location; at least one implantable acoustic receiver receives at least a portion of the acoustic energy, converts the acoustic energy into electrical energy, and delivers the electrical energy to the cardiac tissue; the system detects the delivered electrical energy throughout one or more cardiac cycles to dynamically track three-dimensional (3D) motion data of the implantable acoustic receiver, and maps the cardiac tissue location electromechanically by combining the 3D motion data with EGM data.
Motion magnitude correlation to changes in ejection fraction
An implantable acoustic controller-transmitter comprises an array of acoustic transducers configured to transmit acoustic energy to a cardiac tissue location; at least one implantable acoustic receiver receives at least a portion of the acoustic energy, converts the acoustic energy into electrical energy, and delivers the electrical energy to the cardiac tissue; the system detects the delivered electrical energy throughout one or more cardiac cycles to dynamically track three-dimensional (3D) motion data of the implantable acoustic receiver, determines a magnitude of the motion of the implantable acoustic receiver through the cardiac cycle based on the 3D motion data, and correlates the magnitude of the motion of the implantable acoustic receiver to changes in ejection fraction.
Electromechanical motion profile creation by correlating EGM data with dynamically tracked 3D motion
An implantable acoustic controller-transmitter comprises an array of acoustic transducers configured to transmit acoustic energy to a cardiac tissue location; at least one implantable acoustic receiver-converter receives acoustic energy and converts the acoustic energy into electrical energy, wherein the acoustic receiver-converter comprises two or more electrodes configured to be in electrical connection with tissue and to deliver the electrical energy to the tissue; the system detects the delivered electrical energy continuously throughout one or more cardiac cycles to dynamically track three-dimensional (3D) motion data of the receiver-converter, and correlates EGM data measured at the cardiac tissue location to create an electromechanical motion profile.
Electromechanical map of cardiac tissue location by correlating continuous 3D motion data with EGM
A method for mapping cardiac motion includes transmitting acoustic energy to a location of cardiac tissue using an implantable acoustic controller-transmitter comprising an array of acoustic transducers; converting the transmitted acoustic energy to electrical energy using one or more acoustic receiver-converters; delivering the electrical energy to the cardiac tissue location using two or more electrodes configured to be in electrical connection with the cardiac tissue and to deliver the electrical energy; determining 3D motion data by detecting the electrical energy delivered to the cardiac tissue continuously throughout one or more cardiac cycles; measuring EGM data at the cardiac tissue location; and creating an electromechanical map of the cardiac tissue location by correlating the EGM data and the 3D motion data.
Across the independent claims, the coverage centers on implantable acoustic energy transmission and conversion to electrical energy delivered to cardiac tissue, using delivered electrical-energy detection across one or more cardiac cycles to dynamically track 3D receiver motion and map cardiac tissue motion/location. Several independent claims further extend coverage by normalizing with EKG data, correlating motion profiles with EGM data to create electromechanical motion profiles, combining 3D motion data with EGM data to map electromechanically, correlating motion magnitude with changes in ejection fraction, and creating an electromechanical map by correlating continuous 3D motion data with measured EGM data.
Stated Advantages
Dynamically track three-dimensional (3D) motion data of the implantable acoustic receiver through one or more cardiac cycles.
Map a cardiac motion and map the cardiac tissue location based on the motion profile and/or 3D motion data.
Create electromechanical motion profiles and electromechanical maps by correlating motion profiles and/or 3D motion data with EGM data.
Normalize motion profiles with EKG data.
Correlate motion magnitude with changes in ejection fraction.
Determine 3D motion data continuously by detecting electrical energy delivered to the cardiac tissue.
Documented Applications
Triggering/conditioning pacing stimulation based on end-diastolic position or motion persistence using electromechanical motion profiles.
Determining pacing timing and/or location based on electromechanical motion profiles derived from delivered electrical energy, 3D motion tracking, and correlation/normalization with EKG/EGM data.
Detecting abnormal hemodynamics from premature LV pacing via receiver-stimulator motion and related electromechanical motion profiling.
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