Medicament delivery devices for administration of a medicament within a prefilled syringe
Inventors
Edwards, Eric S. • Edwards, Evan T. • Licata, Mark J. • Meyers, Paul F.
Assignees
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Publication Number
US-11426520-B2
Publication Date
2022-08-30
Expiration Date
Abstract
An apparatus includes a housing, a medicament container and a movable member. The medicament container is movable within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member exerts the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member exerts a retraction force on the flange to move the medicament container from the second position towards the first position.
Core Innovation
The invention provides medicament delivery devices with a housing that defines a gas chamber and an energy storage member configured to produce a pressurized gas within the gas chamber when the energy storage member is actuated. A medicament container assembly is disposed within the housing and includes a container body and an elastomeric member disposed within the container body, with a needle coupled to a distal end portion of the container body. A carrier assembly is coupled to the medicament container assembly and is configured to move within the housing from a first carrier position to a second carrier position in response to actuation of the energy storage member, where the needle is disposed within the housing in the first carrier position and a portion of the needle is disposed outside of the housing in the second carrier position.
The carrier assembly includes a carrier housing defining an internal volume and having a shoulder defining a groove, and the carrier assembly includes a first seal member and an O-ring to fluidically isolate the gas chamber. In one configuration, the first seal member is in sliding contact with an inner surface of the housing, and the O-ring surrounds an outer surface of a proximal end portion of the container body that includes a flange. The O-ring is disposed within the groove, and the proximal end portion of the container body is disposed within the internal volume so that the O-ring is maintained between the shoulder and the flange.
The invention further describes medicament container assemblies including prefilled syringes, together with embodiments that include a movable member and shoulder features that transfer force to the plunger for injection, retraction force features that retract the syringe after delivery, and gas-cavity/pressurized-gas arrangements with valves and gas relief to terminate injection. Additional disclosed variations include needle sheaths, safety lock behavior, cover features for reducing UV/light, valve and gas-valve actuator arrangements, and optional electronic circuit system outputs for an injector system actuator and related indicators.
Claims Coverage
Two independent claims are provided. Each independent claim centers on gas-chamber actuation using an energy storage member and a carrier assembly that shifts between first and second positions while isolating the gas chamber using a seal member and an O-ring arranged relative to a shoulder and a flange.
Gas chamber with pressurized gas energy storage actuation
A housing defines a gas chamber; an energy storage member produces a pressurized gas within the gas chamber when actuated, and the carrier assembly moves within the housing in response to actuation of the energy storage member and changes the disposition of the needle between a first carrier position and a second carrier position.
Seal member and O-ring fluidically isolating the gas chamber at the carrier/flange interface
The carrier assembly includes a first seal member and an O-ring, where the first seal member fluidically isolates the gas chamber and the O-ring is disposed within a groove and maintained between a shoulder and a flange of the container body such that fluid communication from the gas chamber is isolated.
O-ring maintained between shoulder and flange for first-to-second carrier positioning
The carrier assembly includes a shoulder defining a groove, and the carrier assembly positions the container body within an internal volume so that the O-ring is maintained between the shoulder and the flange while the carrier assembly moves from the first carrier position to the second carrier position and a portion of the needle is disposed outside the housing in the second carrier position.
Carrier motion driven by pressurized gas force on proximal carrier surface
The carrier assembly is configured to move within the housing from a first carrier position to a second carrier position in response to a force exerted on a proximal carrier surface by the pressurized gas, with the needle disposed within the housing in the first carrier position and a portion disposed outside the housing in the second carrier position.
Across the independent claims, the main inventive aspects are pressurized-gas generation in a gas chamber from an actuated energy storage member, carrier assembly movement between first and second positions that changes the needle’s disposition, and fluidic isolation of the gas chamber using a first seal member together with an O-ring maintained between a shoulder and a flange on the container body.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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