Compositions and methods for the treatment of malnutrition
Inventors
ZONDAG, Gerben Carolus Martinus • STRIJKER, Reinder
Assignees
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Publication Number
US-11419915-B2
Publication Date
2022-08-23
Expiration Date
Abstract
The present invention relates to novel liquid or semi-liquid nutritional compositions, and powders to generate such liquid or semi-liquid nutritional compositions, that are beneficial in the treatment of malnutrition and malnutrition-related disorders such as weight loss and muscle wasting. When administered regularly, the nutritional compositions according to the present invention contribute to the reversal of malnutrition and malnutrition-related disorders such as weight loss and/or muscle atrophy.
Core Innovation
The invention provides a method for treating a human patient suffering from malnutrition by administering a liquid or semi-liquid nutritional composition. The nutritional composition comprises dairy proteins, vitamin D or a derivative thereof, and ursolic acid.
The dairy proteins have a defined casein:whey ratio, and the amino acid composition includes a mixture of leucine, isoleucine and valine in defined free and bound forms and proportions. The composition is defined by concentration and by an alternative dosing basis per 100 Kcal.
The liquid or semi-liquid nutritional composition comprises 90 to 130 mg/ml dairy proteins, 32 to 55 ng/ml vitamin D or a derivative thereof, and 0.3 to 0.9 mg/ml ursolic acid. The alternative nutritional composition comprises from about 4.0 to about 6.0 grams dairy proteins, from about 1.65 to about 2.2 g vitamin D or a derivative thereof, and from about 25 to about 44 mg ursolic acid.
Claims Coverage
The document contains two independent method claims centered on the same defined combination of dairy proteins, vitamin D or a derivative thereof, ursolic acid, and a specified leucine/isoleucine/valine mixture in free and bound form, with a casein:whey ratio constraint. Across the claims, there are 4 main inventive feature areas.
Treatment of malnutrition in a human patient
A method for treating a human patient suffering from malnutrition by administering the defined nutritional composition.
Defined dairy proteins with casein:whey ratio
The composition comprises dairy proteins at the claimed amounts, with a casein:whey ratio ranging from 45:55 to 65:35.
Vitamin D or derivative thereof and ursolic acid
The composition comprises vitamin D or a derivative thereof and ursolic acid at the claimed amounts.
Leucine, isoleucine and valine mixture in free and bound form
A mixture of leucine, isoleucine and valine is present in free and bound form at the claimed proportions.
Overall, the claims are directed to treating malnutrition in a human patient using a nutritional composition that combines dairy proteins with vitamin D or a derivative thereof and ursolic acid, while specifying a leucine/isoleucine/valine mixture in free and bound form and a casein:whey ratio constraint.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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