Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
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Publication Number
US-11406818-B2
Publication Date
2022-08-09
Expiration Date
Abstract
A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.
Core Innovation
The invention concerns a tissue-penetrating electrochemical sensor for quantifying a chemical or biochemical entity in physiological fluid, featuring a polymer film comprising an electroactive monomer precursor and a selective recognition element on at least a portion of the working electrode. Automated, parallelized co-electrodeposition forms a uniformly dispersed, physically entrapped recognition layer where electrical stimulus controls film thickness and porosity.
The fabrication addresses burdens associated with manual steps, reagent use, manufacturing cost, and sensor-to-sensor variability across single- and multi-sensor configurations. Functionalization applies to two- and three-electrode arrangements utilizing designated selective recognition elements and electroactive monomer precursors.
Claims Coverage
The independent claims comprise three inventive features covering a tissue-penetrating electrochemical sensor device and two fabrication methods.
Sensor device with a recognition-element-containing polymer film
Claim 1 covers a tissue-penetrating electrochemical sensor device for quantifying a chemical or biochemical entity in physiological fluid, comprising an array with a working electrode, a reference electrode, and a counter electrode, with a polymer film comprising an electroactive monomer precursor and a selective recognition element on at least a portion of the working electrode. [procedural detail omitted for safety]
Fabrication by electro-deposition on a working electrode
Claim 9 covers fabrication of a tissue-penetrating electrochemical sensor by forming, on at least a portion of a working electrode within an array of electrodes, a polymer film comprising an electroactive monomer precursor and a selective recognition element. [procedural detail omitted for safety]
Fabrication involving electrodes on multiple sensors
Claim 16 covers fabrication using an array with a working electrode on a first tissue-penetrating electrochemical sensor and at least one additional electrode on a second tissue-penetrating electrochemical sensor to form a polymer film from an electroactive monomer precursor and a selective recognition element. [procedural detail omitted for safety]
Together, the claim elements cover a tissue-penetrating electrochemical sensor device and fabrication methods that utilize electro-deposition to dispose a recognition-element-containing polymer film across single-sensor or multi-sensor electrode arrays.
Stated Advantages
The approach reduces manual steps and reagent use.
The approach reduces manufacturing cost and sensor-to-sensor variability.
The approach enables high-throughput functionalization.
Documented Applications
The sensor is for quantifying a chemical or biochemical entity in a physiological fluid.
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