Substrate having an electron donating surface with metal particles comprising palladium on said surface

Inventors

Ohrlander, Mattias • Södervall, Billy

Assignees

Bactiguard AB

Abstract

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

Core Innovation

The invention relates to an object at least partially coated with an outer layer comprising an electron donating material and metal particles, where the outer layer does not comprise silver. The outer layer characterizes the metal particles as comprising palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum. The metal particle amount is defined from about 0.001 to about 8 μg/cm², and the metal particles have an average size from about 10 to about 10,000 Å.

The disclosure emphasizes providing an electron donating surface on a substrate and uniformly distributing palladium-containing metal particles on that surface in defined amounts. The manufacturing concepts include forming an electron donating layer when needed and depositing metal particles from colloids or suspensions, thereby enabling repeatable, controlled modification of surface properties.

The disclosed targets for surface-property modification include hydrophobicity, protein adsorption, and bacterial adhesion and growth. The disclosure further states measurements related to immune response, including complement activation markers such as C3a/C3b and inflammatory cytokines, together with changes in fibrinogen adsorption and bacterial growth depending on Pd/Au loading.

Claims Coverage

The independent claim covers an object with an outer layer containing an electron donating material and palladium-containing metal particles, excluding silver, with defined metal composition, particle amount, and particle size. Four inventive features are identified across the claim coverage.

The key inventive aspects are the electron donating outer layer excluding silver, the palladium-containing metal particle system with palladium plus one or more specified metals, and the defined metal particle amount and average particle size.

Stated Advantages

Documented Applications