Modular mobile field-deployable laboratory for rapid, on-site detection and analysis of biological targets
Inventors
Jacobs, Jonathan L. • Russell, Joseph A. • Aspinwall, Jacob R.
Assignees
Publication Number
US-11400454-B2
Publication Date
2022-08-02
Expiration Date
2038-01-09
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Abstract
A mobile field-deployable laboratory to more conveniently enable the detecting, sequencing and analyzing of biological agents at the point-of-need. This device enables field operators to go from sample to actionable information in the field without the need for an internet connection or grid-based power. The present mobile laboratory is configured in a footlocker configuration including a plurality of different compartments specifically configured for holding all of the necessary equipment for use in a wide variety of different applications including successfully extracting, amplifying, sequencing and characterizing specific viruses, pathogens and other bacteria directly in the field including an integrated power supply for providing power to the relevant components for up to 72 hours of continuous use without the need for any external power source. The present mobile laboratory includes a deployable workbench area which provides a stable workstation when the footlocker configuration is deployed.
Core Innovation
The invention is a modular, mobile, field-deployable laboratory configured to enable rapid detection, sequencing, and analysis of biological agents at the point of need. This laboratory provides all necessary hardware, reagents, and consumables required to collect samples, extract nucleic acids, perform PCR-based detection, sequence DNA/RNA, and conduct bioinformatics analysis directly in the field, minimizing the reliance on external infrastructure such as internet connections or grid-based power.
The present system is encapsulated in configurations such as an expedition-style backpack or a footlocker, each with dedicated compartments for critical components including a battery array for up to 72 hours of operation, a phase-change cooling system for maintaining reagents and samples at required temperatures, a deployable stable workbench, and specialized compartments for instruments such as a PCR unit and sequencing device. The laboratory is designed for easy transport and quick deployment, allowing rigorous molecular testing and analysis by trained novices in remote locations.
The problem addressed is the logistical and operational challenge of bringing advanced molecular detection and genomic characterization into remote or resource-limited field environments. Existing approaches require transporting samples to fixed laboratories or setting up substantial field bases with generators, cooling, and computational facilities. Prior art lacks a truly portable, integrated system that consolidates all elements necessary for end-to-end biosurveillance and epidemiology workflows, including reliable power, cold-storage, workspace, sample processing, and local data analysis.
Claims Coverage
The patent contains multiple independent claims that define the main inventive features. The most significant inventive features relate to the integrated modular structure, deployable workbench, self-contained ancillary equipment, and portable power/cooling solutions.
Modular field-deployable laboratory structure
A mobile laboratory comprising a first member with an internal cavity, a second hingedly attached member also with at least one cavity, and a workbench member positioned within the first member and movable between a deployed and stored position. The second member is movable between a closed position overlaying the first member and an open position enabling access and partial receipt of the workbench member.
Integrated workbench with adjustable support
A workbench member that divides the cavity of the first member into two portions and is movable between a perpendicular deployed position and an adjacent stored position. At least one leg member supports the workbench in its operational position, with features in some claims including a pair of pivotally connected or adjustable legs.
Mobile backpack unit for ancillary equipment
A mobile backpack unit configured to house ancillary equipment (such as PCR units or DNA sequencing systems), at least partially received within one of the cavities of the second member when the laboratory is closed, and configured for portability and removal for remote operation.
Incorporation of phase-change cooling system
At least one compartment associated with the first member is configured to house a cooling system, including a phase-change cooling system capable of maintaining a defined temperature without external power input for a predetermined duration.
Integrated computer and power subsystem
A computer system for analyzing biological targets, including a monitor structure attachable to the first member. The system includes specific computing elements such as a NUC or CPU, power supply, and modem, all housed within dedicated compartments or monitor structures. The laboratory further contains a power supply compartment, associated outlets, and power strip for self-sufficient operation.
Windshield and specialized workbench attachments
Specific claims describe a windshield member attachable to the workbench, as well as the presence of multiple workbench portions for ergonomic keyboard or instrument placement, with adjustable or foldable features.
Collectively, the inventive features establish a fully integrated, portable laboratory system encompassing modular enclosure, deployable workbench, contained ancillary devices, cold chain capability, onsite power and computing, and ergonomic field usability.
Stated Advantages
Enables field operators to conduct sample collection, nucleic acid extraction, PCR detection, sequencing, and analysis directly in the field without access to an internet connection or grid-based power.
Operates continuously for up to 72 hours with integrated battery and phase-change cooling systems, supporting critical workflows in remote environments.
Provides a stable, deployable workstation and modular compartments for secure storage and rapid deployment of all necessary equipment and reagents.
Reduces laboratory logistical footprint, enabling single-user carriage and deployment even in rugged or inaccessible terrain.
Facilitates rapid, actionable field data generation, supporting biosurveillance, epidemiology, and outbreak response with end-to-end workflows.
Accommodates evolving analytical and storage needs with flexible, customizable internal arrangements adapted to specific missions or targets.
Documented Applications
Point-of-care diagnostics for biological targets in clinical and environmental samples.
Mobile DNA extraction, amplification, and sequencing in the field.
Field forensics, including pathogen and genetic identification from samples collected on-site.
Environmental monitoring and biosurveillance, including disease surveillance of vector populations such as mosquitos.
Sequence-based human identification using DNA traces.
Onsite computational bioinformatics analysis and rapid reporting of sample results.
Water safety testing, food safety testing, and outbreak response.
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