In-situ cross-linkable polymeric compositions and methods thereof
Inventors
Assignees
Publication Number
US-11383005-B2
Publication Date
2022-07-12
Expiration Date
2032-11-12
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Abstract
A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.
Core Innovation
The invention provides a biocompatible polymeric composition that can be cross-linked in-situ within a wound to form a gelatinous matrix that aids wound healing and promotes hemostasis. This composition comprises one or more polyanionic polymers, such as alginates or hyaluronates, which are able to be cross-linked at the surface of the wound, and one or more polycationic polymers, such as chitosan or DEAE-Dextran, that support the solidification process and accelerate blood clotting. Additionally, a cross-linking agent, like aqueous calcium chloride, may be included to further stabilize the composition.
The problem addressed by the invention arises from the limitations of existing wound healing treatments, which often lead to delayed healing, persistent inflammation, reduced granulation and epithelialization, and risk of infection. Current wound dressings either do not provide a desirable protective film on deep wounds after hydration, or require debridement, potentially extending healing time and causing additional patient discomfort. There is a need for a composition that is easily applied, supports tissue healing, reduces inflammation and pain, and does not hinder tissue regeneration or promote chronic wounds.
The invention encompasses methods for formulating and applying this composition so that it rapidly achieves hemostasis without external pressure, provides a biocompatible wound healing matrix, and can be adjusted for viscosity, elasticity, and drug delivery functionalities. Furthermore, the formulation allows for versatile tailoring in terms of thickness and structural characteristics and may be integrated with other therapeutic agents or antimicrobial functionality. The components can be stored and applied in various forms and combined to suit both external and internal wound sites.
Claims Coverage
There are three independent inventive features described in the claims: a biocompatible polymeric composition, a container with the composition, and a kit comprising the composition.
Biocompatible polymeric composition comprising sodium alginate and chitosan in water
A composition containing: - 0.1% to 5% by weight of sodium alginate - 2% to 25% by weight of chitosan - Water as the balance of the composition
Container comprising the biocompatible composition
A container that holds the biocompatible polymeric composition defined above. The container may be a packet, sachet, tube, tub, pump, syringe, bottle, bag, or aerosol-based spray can.
Kit comprising the biocompatible composition
A kit that includes the biocompatible polymeric composition comprising sodium alginate and chitosan in water.
The independent claims cover a specific wound healing composition with defined proportions of sodium alginate and chitosan in water, its storage/applicator container, and kits containing this composition.
Stated Advantages
Rapid achievement of hemostasis without the need to apply pressure.
Provides a biocompatible wound healing matrix conducive to tissue regeneration.
The composition can be adjusted for viscosity and solidification characteristics, allowing controlled formation of thin or thick wound dressings.
Potential for adding antimicrobial agents or drugs to enhance wound healing and infection prevention.
Limits water loss from wounds and provides a durable, protective covering.
Documented Applications
Treatment of external wounds such as lacerations, abrasions, burns, ocular lacerations, superficial cuts and scrapes, and blisters.
Treatment of internal wounds including parenchymal organ damage, internal lacerations, gastrointestinal tract injuries, internal bleeding, arterial and venous bleeds, and dental or oral bleeds.
Use as a matrix for wound healing, blood coagulation, and cosmetic use.
Application as a thick gel for rapid hemostasis.
Application as a protective covering for cuts and scrapes that is durable and limits water loss.
Carrier for therapeutic agents such as drugs, antibiotics, proteins, hormones, and antimicrobial agents for drug delivery.
Use in humans, mammals (e.g. horses, sheep, cattle, hogs, dogs, cats), marine animals (e.g. whales, dolphins, seals, otters, fish), and reptiles (e.g. turtles).
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