Antimicrobial compounds, compositions, and uses thereof
Inventors
Sleet, Randolph B. • Kates, Steven A. • Parkinson, Steven
Assignees
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Publication Number
US-11377468-B2
Publication Date
2022-07-05
Expiration Date
Abstract
A method of treating an infection of at least one of a wound or a ulcer in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof.
Core Innovation
The patent discloses antimicrobial compound Nu-8 (Compound (I)) having a specified Formula (I), including embodiments as pharmaceutically acceptable salts. It further discloses related forms including prodrugs, active metabolites, polymorphic, tautomeric, and solid forms, with sodium salts being notably described.
The disclosed core concept is a method of treating an infection of at least one of a wound or an ulcer in a patient in need thereof by administering an effective amount of the compound of Formula (I) or a pharmaceutically acceptable salt thereof. The described embodiments include topical administration and formulation concepts such as lotion, gel, cream, ointment, paste, oil, powder, solution, and suspension.
The document further emphasizes a pH-dependent potency advantage, stating higher biological activity at pH above about 3, and indicates compatibility with multiple administration routes including topical, inhalation, and intravesical administration. The antimicrobial utility is described across multiple microbe classes and multiple therapeutic indications, including infections associated with diabetic foot ulcers, urinary tract infections, burn wounds, lung infections, otitis externa, bacterial vaginosis, and impetigo.
Claims Coverage
The provided claim set contains one independent claim and refinements. The independent claim covers treating infections of wounds or ulcers in a patient by administering an effective amount of a compound having Formula (I) or a pharmaceutically acceptable salt, with dependent claims adding topical administration, burn wound treatment, combination with at least one additional active ingredient, quantitative dosage constraints, and a specific sodium salt embodiment.
Treating infection of a wound or ulcer by administering Formula (I) compound or salt
A method of treating an infection of at least one of a wound or an ulcer in a patient in need thereof by administering to the patient an effective amount of a compound having Formula (I) or a pharmaceutically acceptable salt thereof.
Topical administration
The method where the administration is performed as topical administration.
Burn wound treatment
The method applied to a burn wound.
Quantitative effective amount range in mg/kg
The method includes administering a compound or a pharmaceutically acceptable salt to a patient within 0.1 to 1000 mg per kg of patient body weight.
Combination with at least one additional active ingredient
The method includes administering at least one additional active ingredient.
Specific sodium salt embodiment
The method is further limited to a specific sodium salt form.
Across the provided claim coverage, the invention centers on administering an effective amount of a Formula (I) antimicrobial compound or a pharmaceutically acceptable salt to treat infections of wounds or ulcers, with added features for topical use, burn wounds, dosage range, combination with an additional active ingredient, and a specified sodium salt form.
Stated Advantages
Higher biological activity at pH above about 3.
Compatibility with multiple administration routes, including topical, inhalation, and intravesical administration.
Documented Applications
Treating infections of wounds or ulcers, including topical treatment of burn wounds and diabetic foot ulcers.
Treating urinary tract infections, including catheter-associated urinary tract infection, via intravesical administration.
Treating lung infections, including infections associated with cystic fibrosis and ventilator acquired pneumonia.
Treating otitis externa.
Treating bacterial vaginosis.
Treating impetigo.
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