Equipment and methodolgies for non-invasive treatment for addiction
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Publication Number
US-11357997-B2
Publication Date
2022-06-14
Expiration Date
Abstract
Methodologies and mechanisms are provided for introducing one or more magnetizable particles introduced non-invasively into one or more body structures containing nervous tissue in a subject, directing, guiding, transporting, focusing and/or concentrating the one or more particles using at least one image-guidance component in proximity to the one or more body structures which can direct the one or more particles within the one or more body structures, and modulating, using at least one activation component, the one or more particles to modulate neuronal function in the one or more body structures of the subject.
Core Innovation
The invention relates to noninvasive administration of one or more magnetizable particles for treating a patient with a neurological disorder. The method performs image-guided magnetic delivery of the one or more magnetizable particles to a neural structure of a subject, and then modulates the neural structure using at least one activation component so as to treat the neurological disorder.
The disclosed approach uses image-guided magnetic delivery components positioned in proximity to the neural structure to direct and/or propel and/or concentrate the magnetizable particles within one or more body structures under imaging guidance. The document describes an MRI-based image-guidance arrangement with electropermanent magnets and/or electromagnets for proximal image-guidance, and particle targeting to structures including the nucleus accumbens and other neural structures.
The system further uses an activation component separate from the image-guidance components to stimulate neurons by inducing particle motion and/or vibration. The document discusses that the magnetizable particles can degrade and/or dissolve so particles do not remain permanently, and it notes rapid application to reduce bio-effects with possible outpatient treatment. Figure-based embodiments and component configurations/placement are described for the image-guided delivery and the activation component.
Claims Coverage
The independent claim set contains one independent method claim (clm-00001) directed to image-guided magnetic delivery of magnetizable particles and subsequent neuromodulation using an activation component, with dependent claims refining the delivery and neuromodulation context and adding specific constraints (e.g., microsecond timing and particle degradation).
Image-guided magnetic delivery to a neural structure
Performing image-guided magnetic delivery of the one or more magnetizable particles to a neural structure of a subject.
Neural modulation using an activation component
Modulating the neural structure with at least one activation component so as to treat the neurological disorder.
Proximate image-guidance component directs particle placement within body structures
The image-guided magnetic delivery is performed using at least one image-guidance component positioned in proximity to the neural structure to direct the one or more magnetizable particles within one or more body structures.
MRI pulse sequences with rise-time, fall-time, or duration less than 10 microseconds
The MRI system generates pulse sequences whose rise-time, fall-time, or duration are less than 10 microseconds long.
Magnetic coil field rise or fall in less than 10 microseconds
The at least one magnetic coil generates a magnetic field that rises or falls in less than 10 microseconds.
Neuromodulation by moving magnetizable particles in the neural structure
Neuromodulation is implemented by moving the one or more magnetizable particles in the neural structure.
Magnetizable particles degrade in less than one month
The one or more magnetizable particles degrade in less than one month.
Overall, the claim coverage centers on noninvasive treating of a neurological disorder by combining image-guided magnetic delivery of magnetizable particles to a neural structure with activation-component-based modulation, with refinements including proximate image-guidance to direct particles within body structures, MRI and coil timing constraints, neuromodulation via movement of particles, and particle degradation within less than one month.
Stated Advantages
Noninvasive administration.
Rapid application to reduce bio-effects.
Possible outpatient treatment.
Magnetizable particles degrade and/or dissolve so particles do not remain permanently.
Documented Applications
Treating a patient with a neurological disorder, including addiction, using noninvasive image-guided magnetic delivery and neural modulation with an activation component.
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