Intraosseous implanted biological sensor
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Publication Number
US-11357425-B2
Publication Date
2022-06-14
Expiration Date
Abstract
A method and system for monitoring analytes in the circulatory system of an individual is provided. A biological sensor is implanted in the bone marrow of a patient and may be self contained within a housing. The biological sensor measures physiological parameters of a patient, including analytes, on a fixed or adjustable schedule. The biological sensor includes a control unit having a transmitter and an energy source for providing energy to the control unit. The biological sensor may be used to adjust other medical treatments and devices in a closed or semi closed loop mechanism and/or predict patient treatment.
Core Innovation
The invention relates to a sensor system for measuring one or more analytes in a subject using an implantable sensor device configured for implantation into a bone marrow region. The implantable sensor device includes a housing with an interior and one or more sensing units included within the housing in communication with a housing control unit. The sensing units generate analyte data corresponding to the bone marrow region upon implantation.
The housing is provided with a porous membrane covering at least a part of the housing, the porous membrane being configured to allow analytes from outside the housing to enter the interior of the housing and contact the one or more sensing units. The housing control unit is positioned within the housing and comprises a transmitter and a receiver. The sensor system is configured for collection and analysis of analyte data corresponding to the bone marrow region of the subject upon implantation.
Power is provided by an energy source positioned within the housing for providing energy to the housing control unit, where the energy source comprises a self-generating system configured to use at least one of motion flow, vascular flow, body heat, or chemical reaction for generation of energy. The system enables analyte data to be collected and analyzed from within the bone marrow region using implantable components, internal communication, and membrane-enabled analyte access.
Claims Coverage
The document provides one independent claim, with dependent claims refining the system architecture, data handling, sensing schedules, and optional treatment/medication delivery based on analyte data. The independent claim includes four core inventive areas: implantation into a bone marrow region, porous membrane analyte access to internal sensing units, an internal control unit with transmitter/receiver, and an internally powered self-generating energy source using motion flow, vascular flow, body heat, or chemical reaction.
Bone marrow implanted analyte sensor device with data collection and analysis
An implantable sensor device configured for implantation into a bone marrow region of the subject, where the sensor system is configured for collection and analysis of analyte data corresponding to the bone marrow region upon implantation.
Porous membrane for analyte entry to internal sensing units
A porous membrane covering at least a part of the housing, configured to allow analytes from outside the housing to enter the interior of the housing and contact the one or more sensing units.
Housing control unit with transmitter and receiver
A housing control unit positioned within the housing, the control unit comprising a transmitter and a receiver, with one or more sensing units in communication with the housing control unit.
Self-generating in-housing energy from motion flow, vascular flow, body heat, or chemical reaction
An energy source positioned within the housing for providing energy to the housing control unit, the energy source comprising a self-generating system configured to use at least one of motion flow, vascular flow, body heat, or chemical reaction for generation of energy.
Overall claim coverage centers on an implantable bone marrow sensor system that collects and analyzes analyte data using internal sensing units accessed through a porous membrane, an in-housing transmitter/receiver control unit, and an in-housing self-generating energy source derived from motion flow, vascular flow, body heat, or chemical reaction.
Stated Advantages
Documented Applications
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