Continuous autoregulation system
Inventors
OZIEL, Moshe • Rubinsky, Boris • LEVINSON, Mitchell Elliott • Shusterman, Eugene Mark
Assignees
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Publication Number
US-11357417-B2
Publication Date
2022-06-14
Expiration Date
Abstract
A method for measuring an intracranial bioimpedance in a patient's head, to help evaluate cerebral autoregulation, may involve securing a volumetric integral phase-shift spectroscopy (VIPS) device to the patient's head, measuring the intracranial bioimpedance with the VIPS device by measuring a phase shift between a magnetic field transmitted from a transmitter on one side of a VIPS device and a magnetic field received at a receiver on another side of the VIPS device, at one or more frequencies, and evaluating cerebral autoregulation in the intracranial bioimpedance, using a processor in the VIPS device.
Core Innovation
The disclosure describes a continuous, noninvasive intracranial monitoring system using a head-worn volumetric integral phase-shift spectroscopy (VIPS) device secured to the patient. The VIPS device measures intracranial bioimpedance by measuring phase shifts between a transmitter magnetic field and a receiver magnetic field at one or more frequencies through portions of the head.
The VIPS processor evaluates cerebral autoregulation in the intracranial bioimpedance using measured phase shifts. The evaluation includes identifying a difference between a first phase shift through a left half of the patient's head and a second phase shift through a right half of the patient's head, the difference corresponding to an asymmetry between the left half and the right half of the patient's head.
The disclosure further supports evaluating changes by comparing baseline and later phase shifts and/or computing asymmetry between left and right hemispheres. The processor optionally uses thresholds, indices based on a formula, and difference between indices to generate outputs such as an indicator or an alarm.
Claims Coverage
The document includes one independent method claim with multiple dependent claims that refine how cerebral autoregulation is evaluated from VIPS-measured intracranial bioimpedance phase shifts. The independent claim centers on left/right hemispheric phase-shift asymmetry for autoregulation evaluation, with dependents adding baseline-versus-later change detection, thresholding, formula-based indices, index-difference evaluation, and alarm generation based on abnormal change or rate of change.
VIPS device secured to the patient's head
Securing a volumetric integral phase-shift spectroscopy (VIPS) device to the patient's head so intracranial bioimpedance can be measured.
Phase shift measurement using transmitter and receiver magnetic fields at one or more frequencies
Measuring the intracranial bioimpedance with the VIPS device by measuring a phase shift between a magnetic field transmitted from a transmitter on one side of a VIPS device and a magnetic field received at a receiver on another side of the VIPS device at one or more frequencies.
Left and right phase shifts for asymmetry
Measuring a first phase shift through a left half of the patient's head and measuring a second phase shift through a right half of the patient's head.
Processor evaluation of cerebral autoregulation using left/right asymmetry
Evaluating cerebral autoregulation in the intracranial bioimpedance using a processor in the VIPS device by identifying a difference between the first phase shift and the second phase shift corresponding to an asymmetry between the left half and the right half of the patient's head.
Baseline versus later change evaluation
Evaluating cerebral autoregulation by comparing a baseline phase shift with a second phase shift at a later time, and identifying the change between them.
Threshold for autoregulation or intracranial compliance
Detecting cerebral autoregulation and/or intracranial compliance by determining whether the change between a baseline phase shift and a second phase shift meets, exceeds, or falls below a threshold.
Formula-based index from phase shifts
Defining an index using a mathematical formula based on a first phase shift and a second phase shift.
Index difference evaluation
Evaluating cerebral autoregulation by detecting a difference between a first index associated with a first phase shift and a second index associated with a second phase shift.
Alarm based on abnormal change or rate of change
Detecting an abnormal change or rate of change and sounding an alarm on a VIPS device.
Claim coverage centers on left/right hemispheric asymmetry derived from VIPS-measured phase shifts and processed in the VIPS processor to evaluate cerebral autoregulation. Dependent claims broaden this by comparing baseline versus later phase shifts, applying thresholds, generating formula-based indices, evaluating differences between indices, and issuing an alarm in response to abnormal change or rate of change.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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