Heating mechanism for biochemical reaction device
Inventors
Lee, Chun-Ming • Lin, Ching-Ko • Tsai, Yun-Lung • Lee, Pei-Yu • Su, Chen • CHANG, Hsiao-Fen • LI, FU-CHUN
Assignees
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Abstract
Provided is a heating mechanism for a biochemical reaction device, including: a heat-conducting body including: at least one accommodating groove each including a chamber and an opening communicating with the chamber; a clamping hole, in communication with the opening and for inserting a reaction tube; and at least one heat-conducting block, movably disposed in the chamber and having one end connected with an elastic element and another opposite end provided with an abutting portion, the elastic element enabling the abutting portion of the heat-conducting block to protrude from the opening and locate in the clamping hole; and a temperature control element connected to the heat-conducting body for heating and regulating a temperature of the heat-conducting block. The heat-conducting blocks of the heating mechanism can be in direct and assured contact with the reaction tube for conducting heat, so that the solution in the reaction tube can easily and assuredly reach a preset temperature, thereby achieving a consistent reaction condition and increasing the accuracy of the reaction result.
Core Innovation
The invention is a heating mechanism for a biochemical reaction device that includes a heat-conducting body having at least one accommodating groove. Each accommodating groove comprises a chamber and an opening communicating with the chamber, and the heat-conducting body further includes a clamping hole that is in communication with the opening and is configured for insertion of a reaction tube.
At least one heat-conducting block is movably disposed in the chamber and has one end connected to an elastic element and another opposite end provided with an abutting portion. The elastic element enables the abutting portion of the heat-conducting block to protrude from the opening and locate in the clamping hole, so that the reaction tube is clamped in place. A temperature control element is connected to the heat-conducting body for heating and regulating a temperature of the heat-conducting block.
The described variants configure the accommodating grooves and openings so they are circumferentially distributed around the clamping hole and include a limiting member and a through-hole communication between the temperature control element and the clamping hole. Additional variants specify abutting portion geometries for the heat-conducting block and can include a heat-conducting element on the reaction tube that is clamped into contact for heat conduction. The document further describes a heat-dissipation hole for rapid cool-down, supporting preset temperature attainment and regulated thermal behavior.
Claims Coverage
Independent claim clm-00001 covers a heating mechanism in which a heat-conducting body with accommodating grooves and a clamping hole receives a reaction tube, while elastically urged, movably disposed heat-conducting blocks protrude to clamp the tube and a temperature control element heats and regulates the heat-conducting blocks. Dependent claims refine the geometric arrangement of grooves/openings, temperature control element positioning, abutting portion shape, and the inclusion of a limiting member with through-hole communication, and can add a reaction container with a heat-conducting element.
Movably disposed heat-conducting blocks elastically protruding to clamp a reaction tube
The heating mechanism includes at least one heat-conducting block movably disposed in the chamber, with one end connected to an elastic element and another opposite end provided with an abutting portion, where the elastic element enables the abutting portion to protrude from the opening and locate in the clamping hole to clamp the reaction tube.
Accommodating grooves forming chambers and openings communicating with the clamping hole
The heating mechanism includes a heat-conducting body having at least one accommodating groove each comprising a chamber and an opening communicating with the chamber, and a clamping hole in communication with the opening for insertion of a reaction tube.
Temperature control element heating and regulating the heat-conducting block
The heating mechanism includes a temperature control element connected to the heat-conducting body for heating and regulating a temperature of the heat-conducting block.
Across the claims, the inventive concept centers on combining a groove-and-clamping-hole heat-conducting body with movably disposed, elastically urged heat-conducting blocks that protrude to clamp the reaction tube, together with a temperature control element that heats and regulates the heat-conducting block.
Stated Advantages
More uniform/preset temperature attainment.
Improved reaction reproducibility and accuracy.
Improved reaction efficiency and product yield.
Compact volume.
Shortened reaction time/thermal cycling.
Documented Applications
Used in a biochemical reaction device such as polymerase chain reaction (PCR).
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