Process for hydrolysis of oligosaccharides
Inventors
Sanderson, Charles Sebastian • Beacom, Daniel Roger
Assignees
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Publication Number
US-11326216-B2
Publication Date
2022-05-10
Expiration Date
Abstract
Provided is a method comprising (a) providing a hydrolysis composition of at least 20 wt % of sugar equivalents, wherein the hydrolysis composition comprises a first oligosaccharide, water, optionally a soluble aromatic compound, (b) contacting the hydrolysis composition with a catalyst in a first reactor to hydrolyze at least a portion of the first oligosaccharide to form a first product composition comprising a first monosaccharide and a second oligosaccharide, (c) separating the first monosaccharide from the first product composition to form a second product composition comprising the second oligosaccharide, wherein at least a portion of the second oligosaccharide is a reversion sugar, and (d) converting via a further hydrolysis step at least a portion of the second oligosaccharide to form a third product composition comprising a second monosaccharide.
Core Innovation
A method provides a hydrolysis composition having at least 20% of sugar equivalents, the hydrolysis composition including a first oligosaccharide, water, and optionally a soluble aromatic compound and optionally organic and/or inorganic impurities. The hydrolysis composition is contacted with a catalyst in a first reactor to hydrolyze at least a portion of the first oligosaccharide and form a first product composition comprising a first monosaccharide and a second oligosaccharide.
The first monosaccharide is separated from the first product composition to form a second product composition comprising the second oligosaccharide, wherein at least a portion of the second oligosaccharide is a reversion sugar. At least a portion of the second oligosaccharide is converted via a further hydrolysis step to form a third product composition comprising a second monosaccharide.
In another method, at least a portion of the second oligosaccharide is recycled back to the first reactor and the contacting step is repeated using the portion of the second oligosaccharide as at least a portion of the first oligosaccharide. The catalyst is an acid and the method further comprises adjusting the pH of the third product composition with a base.
Claims Coverage
The document provides two independent claims. Each independent claim covers multi-stage hydrolysis with separation of monosaccharides from a reversion-sugar-containing oligosaccharide fraction, followed by conversion to a second monosaccharide, with differing requirements for reactor arrangement and pH adjustment with a base.
Multi-stage hydrolysis of a reversion-sugar-containing oligosaccharide fraction
Contacting a hydrolysis composition of at least 20% sugar equivalents with a catalyst in a first reactor to hydrolyze a first oligosaccharide to a first product composition comprising a first monosaccharide and a second oligosaccharide, separating the first monosaccharide to form a second product composition comprising the second oligosaccharide where at least a portion is a reversion sugar, and converting at least a portion of the second oligosaccharide via a further hydrolysis step to form a third product composition comprising a second monosaccharide.
Recycling of a reversion-sugar-containing oligosaccharide fraction
Contacting a hydrolysis composition of at least 20% sugar equivalents with a catalyst in a first reactor to hydrolyze a first oligosaccharide to a first product composition comprising a first monosaccharide and a second oligosaccharide, separating the first monosaccharide to form a second product composition comprising the second oligosaccharide where at least a portion is a reversion sugar, converting at least a portion of the second oligosaccharide via a further hydrolysis step to form a third product composition comprising a second monosaccharide, and recycling at least a portion of the second oligosaccharide back to the first reactor using the portion as at least a portion of the first oligosaccharide.
Acid-catalyzed hydrolysis with pH adjustment
The catalyst is an acid and the method further comprises adjusting the pH of the third product composition with a base.
Across the independent claims, the core coverage is directed to isolating an oligosaccharide fraction that includes reversion sugars after an initial hydrolysis stage, and then hydrolyzing that fraction further to form a second monosaccharide, either in a second reactor or by recycling back to the first reactor, with the acid-catalyzed embodiment further requiring pH adjustment with a base.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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