Nanoparticles for chemiresistor sensors
Inventors
Pasca, Yair • Kapilov, Katya • Hirsch, Maayan • Israel, Sima • Zanti, Yahel
Assignees
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Publication Number
US-11307158-B1
Publication Date
2022-04-19
Expiration Date
Abstract
A nanoparticle characterized by sensitivity to an analyte of interest, and comprising a conductive core in contact with a plurality of ligands bound to the conductive core is disclosed. Additionally, a chemiresistor sensor comprising the nanoparticles of the invention and a method of using thereof such as for detection of an analyte of interest in a gaseous sample are disclosed.
Core Innovation
The disclosed invention concerns a nanoparticle having a conductive core in contact with a plurality of ligands, where each ligand includes a first moiety capable of binding to the core and a second moiety covalently bound to the first moiety. The plurality of ligands is assembled to form a shell on top of the core, and the nanoparticle is characterized by sensitivity to an analyte of interest.
A central aspect of the invention is the structure of the ligand shell, including covalently bound ligand components with defined binding and alkyl-aryl architecture. The second moiety is an alkyl-aryl moiety comprising at least 2 aliphatic carbon atoms, and the shell structure may include self-assembled monolayer character and a range of core/shell property relationships.
The nanoparticle and sensor configuration are presented as improving selectivity and sensitivity to VOC analytes, specifically optionally unsaturated C1-C20 aldehydes and optionally unsaturated C1-C20 alkanes. A chemiresistor sensor includes at least two electrodes and a sensing element electrically connected to the electrodes, where the sensing element is made from a structure formed from the nanoparticle shell-coated cores.
Claims Coverage
The independent claims are clm-00001 and clm-00014. Across these claims, there are two core inventive concepts: a specific shell-forming nanoparticle architecture and its use as a chemiresistor sensor for sensitivity to VOC analytes including optionally unsaturated C1-C20 aldehydes and/or optionally unsaturated C1-C20 alkanes.
Nanoparticle with conductive core and shell-forming covalently assembled ligands
A nanoparticle comprising a conductive core in contact with a plurality of ligands bound to said core, wherein each ligand comprises a first moiety capable of binding to the core and a second moiety covalently bound to said first moiety; the plurality of ligands are assembled to form a shell on top of said core; and wherein said nanoparticle is characterized by sensitivity to an analyte of interest.
Alkyl-aryl second moiety with at least two aliphatic carbon atoms
The nanoparticle wherein the second moiety is an alkyl-aryl moiety comprising at least 2 aliphatic carbon atoms.
Chemiresistor sensor with electrodes and nanoparticle sensing element
A chemiresistor sensor comprising at least two electrodes and a sensing element electrically connected to the two electrodes and comprising a structure made from a plurality of nanoparticles.
Metal core nanoparticles with first-moiety binding and covalently bound alkyl-aryl ligands
The chemiresistor sensor wherein each nanoparticle comprises a metal core in contact with a plurality of ligands bound to said core; each ligand comprises a first moiety or a salt thereof capable of binding to the core, and an alkyl-aryl moiety covalently bound to said first moiety; the plurality of ligands are assembled to form a shell on top of said core.
Sensitivity to VOC analytes selected from optionally unsaturated aldehydes and alkanes
The chemiresistor sensor wherein said nanoparticle is characterized by sensitivity to an analyte of interest comprising a volatile organic compound (VOC) selected from an optionally unsaturated C1-C20 aldehyde, and an optionally unsaturated C1-C20alkane.
Overall, the claims cover a conductive or metal core nanoparticle with a shell formed by ligands having a core-binding first moiety and a covalently bound alkyl-aryl second moiety, together with a chemiresistor sensor using such nanoparticles as the sensing element for VOC analytes.
Stated Advantages
Enhanced selectivity/sensitivity to VOC analytes, including optionally unsaturated C1-C20 aldehydes and optionally unsaturated C1-C20 alkanes.
Characterization based on conductivity/resistivity-derived signals to determine presence and optionally concentration of VOC analytes at ppb-ppm levels.
Documented Applications
Analyzing/analyte sensing for VOC analytes selected from optionally unsaturated C1-C20 aldehydes and/or optionally unsaturated C1-C20 alkanes using a chemiresistor sensor based on the disclosed shell-coated nanoparticles.
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