Hemostatic textile
Inventors
Fischer, Thomas H. • Eskridge, E. Stan • Malloy, William M. • Evans, Malloy
Assignees
Eniegrion Inc • University of North Carolina at Chapel Hill • Entegrion Inc
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Publication Number
US-11304852-B2
Publication Date
2022-04-19
Expiration Date
Abstract
The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyimide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.
Core Innovation
A packaged hemostatic textile is provided with a textile material comprising glass fibers cowoven or knitted with bamboo rayon fibers. When the textile material is in contact with a wound on an animal or human, hemostatic systems are activated in the animal or human. The textile material is packaged in a sterilized package.
In embodiments, the glass fibers are continuous and have a diameter ranging from 5 nanometers to 15 microns, and the glass fibers may be made of aluminoborosilicate glass. The textile material includes thrombin or a thrombin-containing fraction to support activation of hemostatic systems upon wound contact.
The textile material may further include a hemostatic agent selected from rehydrated lyophilized platelets, rehydrated lyophilized blood cells, fibrin, fibrinogen, or combinations thereof. The disclosed concept connects wound contact with activation of hemostatic systems using glass fibers paired with bamboo rayon fibers in a packaged, sterilized format.
Claims Coverage
The document provides three independent claims. Across these independent claims, the inventive features center on a packaged or non-packaged hemostatic textile that cowoven or knitted glass fibers with bamboo rayon fibers to activate hemostatic systems upon wound contact, optionally including thrombin and additional hemostatic agents as recited in dependent claims.
Packaged hemostatic textile with glass fibers cowoven or knitted with bamboo rayon fibers
A packaged hemostatic textile in which a textile material comprising glass fibers cowoven or knitted with bamboo rayon fibers activates hemostatic systems in an animal or human when the textile material is in contact with a wound, and the textile material is packaged in a sterilized package.
Packaged woven or knitted hemostatic textile activating hemostatic systems with bamboo rayon fibers
A packaged hemostatic textile having a woven or knitted textile material that activates hemostatic systems in an animal or human when the woven or knitted textile material is in contact with a wound, where the woven or knitted textile material is packaged in a sterilized package and the textile comprises bamboo rayon fibers.
Hemostatic textile with glass fibers cowoven or knitted with bamboo rayon fibers
A hemostatic textile comprising glass fibers cowoven or knitted with bamboo rayon fibers, wherein when the hemostatic textile is in contact with a wound on an animal or human, hemostatic systems are activated in the animal or human.
Overall claim coverage focuses on wound-contact activation of hemostatic systems by combining glass fibers with bamboo rayon fibers in cowoven or knitted textile forms, and, for two independent claims, providing the textile in a sterilized package. Dependent claims further cover specific glass fiber configurations and optional hemostatic components such as thrombin or thrombin-containing fractions and selected rehydrated lyophilized platelet, blood-cell, fibrin, and fibrinogen agents.
Stated Advantages
Rapid hemostasis via localized high concentrations.
Storage stability using lyophilized proteins.
Documented Applications
Wound dressing/bandage/tourniquet use is described in connection with a hemostatic textile that activates hemostatic systems upon wound contact.
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