Detection and modification of gut microbial population
Inventors
Matson, Wayne R. • Matson, Samantha A. • Ebbel-Angle, Erika N. • Sarangi, Srikant
Assignees
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Publication Number
US-11287420-B2
Publication Date
2022-03-29
Expiration Date
Abstract
Methods and systems for evaluating heath/disease state of an individual are provided herein. In particular, the disclosure provides methods for measuring levels of one or more metabolites of interest in an individual and using these measurements to assess the individual's health. The disclosure also provides systems for carrying out the disclosed methods. For example, the disclosed systems may include a metabolite level evaluation module to determine the individual's heath based on the metabolite levels measured.
Core Innovation
The invention provides a method for improving the gut health, emotional balance, cognitive acuity, energetic efficiency and immuno fitness of an individual in need of improvement by using fluid sample analysis of microbiome modified compounds. The method includes collecting fluid samples, analyzing them for specified concentrations of microbiome modified compounds, and comparing those concentrations to standards concentrations.
After comparison to standards, the method provides for oral administration of one or more supplements selected from a group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol. The supplements are administered to raise or reduce the concentration, as the case may be, of components of the gut microbiome of the individual that effect the microbiome modified compounds whose measured concentrations fall outside of the standards concentrations.
The method repeats the fluid sample analysis and supplement administration cycle to bring the measured concentrations to within the standards concentrations. The fluid sample may be collected as blood, urine, or tears, and the standards concentrations are defined by collecting and analyzing fluid samples from a plurality of different individuals.
Claims Coverage
The independent claims cover a repeating, standards-based, fluid-sample guided regimen to improve gut health and multiple systemic attributes by measuring specific microbiome modified compounds and orally administering selected supplements to raise or reduce concentrations. Across the independent claims, the inventive features repeatedly include fluid sample collection and targeted compound concentration analysis, comparison to standards concentrations, oral administration of selected supplements from a defined group, and repeating the cycle until measurements fall within standards, with variations in the specific compound set and sample matrix.
Repeating standards-based gut health improvement cycle using fluid sample analysis
Collecting fluid samples from an individual; analyzing the fluid samples for concentration of microbiome modified compounds; comparing the concentration of said microbiome modified compounds to standards concentrations; providing for oral administration of one or more supplements selected from the group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol to raise or reduce concentrations associated with gut microbiome components; and repeating steps (1) to (4) to bring the measured concentrations to within the standards concentrations.
Targeted microbiome modified compounds measured in the fluid samples
Analyzing said fluid samples for concentration of indole propionic acid (IPA), indole-3-lactic acid (ILA), indole-3-acetic acid (IAA), Tryptophan (TRP), Kynurenine (KYN), Total Indoxyl Sulfate (IDS), Tyrosine (TYR), and Uric Acid (UA) as microbiome modified compounds, and in other coverage, additionally or alternatively analyzing Serotonin (SER) or 3-Methylxanthine (3MXAN) as part of the microbiome modified compounds.
Standards concentrations derived from multiple individuals
Comparing measured concentrations to standards concentrations where the standards concentrations are created by collecting and analyzing fluid samples from a plurality of different individuals.
Oral administration of selected supplements from a defined group to adjust microbiome-associated compounds
Providing for oral administration to said individual one or more supplements selected from the group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol, where the supplements are provided to raise or reduce the concentration, as the case may be, of components of the gut microbiome of said individual that effect the microbiome modified compounds that have measured concentrations falling outside of the standards concentrations.
Overall, the independent claims focus on a cycle that uses fluid sample measurement of specific microbiome modified compounds, compares results to standards concentrations, administers oral supplements selected from a defined group to adjust gut microbiome-related effects on those compounds, and repeats until measured concentrations are within standards. Variations in the compound list, including SER and 3MXAN in some coverage, and the fluid sample type, including blood, urine, or tears, further define claim scope, while standards concentrations are established using samples from multiple individuals.
Stated Advantages
Improving gut health.
Improving emotional balance.
Improving cognitive acuity.
Improving energetic efficiency.
Improving immuno fitness.
Documented Applications
A method for improving the gut health, emotional balance, cognitive acuity, energetic efficiency and immuno fitness of an individual in need of improvement.
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