Detection and modification of gut microbial population
Inventors
Matson, Wayne R. • Matson, Samantha A. • Ebbel-Angle, Erika N. • Sarangi, Srikant
Assignees
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Publication Number
US-11287419-B2
Publication Date
2022-03-29
Expiration Date
Abstract
Methods and systems for evaluating health/disease state of an individual are provided herein. In particular, the disclosure provides methods for measuring levels of one or more metabolites of interest in an individual and using these measurements to assess the individual's health. The disclosure also provides systems for carrying out the disclosed methods. For example, the disclosed systems may include a metabolite level evaluation module to determine the individual's heath based on the metabolite levels measured.
Core Innovation
The invention relates to a method for improving gut health, emotional balance, cognitive acuity, energetic efficiency and immuno fitness of an individual in need of improvement. The method repeatedly collects fluid samples from the individual, analyzes the concentration of microbiome modified compounds in the fluid, and compares the measured concentrations to standards concentrations. The method then provides for oral administration of selected supplements intended to raise or reduce microbiome-related components that affect the microbiome modified compounds whose measured concentrations fall outside the standards concentrations.
The analyzed microbiome modified compounds include indole propionic acid (IPA), indole-3-lactic acid (ILA), indole-3-acetic acid (IAA), tryptophan (TRP), kynurenine (KYN), total indoxyl sulfate (IDS), tyrosine (TYR), xanthine (XAN), and uric acid (UA), with an embodiment also including serotonin (SER). After the comparing step, the method provides oral administration of one or more supplements selected from a group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol.
The method is characterized by a sequential loop in which steps of collecting, analyzing, comparing, providing oral administration, and repeating are used to bring the measured concentrations to within the standards concentrations. Standards concentrations are used as reference values, and in embodiments they are generated by collecting and analyzing fluid samples from a plurality of different individuals. The disclosed method allows selection of fluid samples including blood, urine, or tears, and allows oral administration of two or more supplements selected from the stated group.
Claims Coverage
The provided material identifies three independent methods. Each independent claim includes a sequential workflow: collecting fluid samples, analyzing specified microbiome modified compounds, comparing to standards concentrations, orally administering selected supplements from a defined group to adjust microbiome-related components, and repeating until measured concentrations are within the standards. The independent claims differ mainly in the included microbiome modified compound panel, and one includes serotonin.
Sequential evaluation and oral supplementation based on microbiome modified compound concentrations
The method consists of collecting fluid samples, analyzing the fluid samples for concentration of specified microbiome modified compounds, comparing the concentration to standards concentrations, providing for oral administration to the individual of one or more supplements selected from a group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol to raise or reduce components of the gut microbiome that effect microbiome modified compounds measured outside the standards, and repeating steps (1) to (4) to bring the measured concentrations to within the standards concentrations.
Expanded microbiome modified compound panel including serotonin
The method consists of collecting fluid samples, analyzing the fluid samples for concentration of microbiome modified compounds including indole propionic acid (IPA), indole-3-lactic acid (ILA), indole-3-acetic acid (IAA), tryptophan (TRP), serotonin (SER), kynurenine (KYN), total indoxyl sulfate (IDS), tyrosine (TYR), and uric acid (UA), comparing the concentration to standards concentrations, providing for oral administration to the individual of one or more supplements selected from a group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol to raise or reduce gut microbiome components affecting microbiome modified compounds outside the standards, and repeating steps (1) to (4) to bring the measured concentrations to within the standards concentrations.
Oral adjustment regimen targeting microbiome-related components to meet standards
The method consists of collecting fluid samples, analyzing the fluid samples for concentration of microbiome modified compounds including indole propionic acid (IPA), indole-3-lactic acid (ILA), indole-3-acetic acid (IAA), tryptophan (TRP), serotonin (SER), kynurenine (KYN), total indoxyl sulfate (IDS), tyrosine (TYR), and xanthine (XAN), comparing the concentration to standards concentrations, providing for oral administration to the individual of one or more supplements selected from a group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol to raise or reduce gut microbiome components affecting microbiome modified compounds outside the standards, and repeating steps (1) to (4) to bring the measured concentrations to within the standards concentrations.
Across the independent claims, the claim coverage centers on a repeated cycle of fluid-sample analysis of a defined panel of microbiome modified compounds, comparison to standards concentrations, and oral administration of supplements selected from prebiotic, probiotic, vitamin B complex, and CoQ10 protocol to adjust gut microbiome components until the measured concentrations fall within the standards.
Stated Advantages
Improving the gut health of an individual in need of improvement.
Improving emotional balance, cognitive acuity, energetic efficiency and immuno fitness of the individual.
Raising or reducing gut microbiome components that affect microbiome modified compounds whose concentrations fall outside standards concentrations.
Bringing measured concentrations to within the standards concentrations through repeating steps (1) to (4).
Documented Applications
Improving gut health, emotional balance, cognitive acuity, energetic efficiency and immuno fitness of an individual in need of improvement by analyzing microbiome modified compounds in fluid samples and administering selected supplements.
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