Detection and modification of gut microbial population

Inventors

Matson, Wayne R. • Matson, Samantha A. • Ebbel-Angle, Erika N. • Sarangi, Srikant

Assignees

Ixcela Inc

Abstract

Methods and systems for evaluating heath/disease state of an individual are provided herein. In particular, the disclosure provides methods for measuring levels of one or more metabolites of interest in an individual and using these measurements to assess the individual's health. The disclosure also provides systems for carrying out the disclosed methods. For example, the disclosed systems may include a metabolite level evaluation module to determine the individual's heath based on the metabolite levels measured.

Core Innovation

The invention provides a method for improving the gut health, emotional balance, cognitive acuity, energetic efficiency and immuno fitness of an individual in need of improvement. The method collects fluid samples from the individual and analyzes the samples for concentration of microbiome modified compounds in the fluid samples, including indole propionic acid (IPA), indole-3-lactic acid (ILA), indole-3-acetic acid (IAA), Tryptophan (TRP), Serotonin (SER), Kynurenine (KYN), Total Indoxyl Sulfate (IDS), Tyrosine (TYR), Xanthine (XAN), 3-Methylxanthine (3MXAN) and Uric Acid (UA).

The method compares the concentration of the microbiome modified compounds to standards concentrations. Based on whether the measured concentrations fall outside of the standards concentrations, the method provides for oral administration to the individual one or more supplements selected from a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol to raise or reduce the concentration of components of the gut microbiome of the individual that effect the one or more microbiome modified compounds.

The method repeats the collecting, analyzing, comparing, and providing steps to bring the measured concentrations to within the standards concentrations. Dependent claim refinements identify that the fluid samples can comprise blood, urine, or tears, that the standards concentrations can be generated by collecting and analyzing fluid samples from a plurality of different individuals, and that two or more selected supplements can be administered.

Claims Coverage

The document provides three independent method claims. Across the independent claims, the inventive core includes collecting fluid samples, analyzing defined microbiome modified compounds, comparing the concentrations to standards concentrations, providing oral supplements, and repeating the steps until the measured concentrations are within the standards.

The claim coverage centers on an iterative method that measures concentrations of defined microbiome modified compounds in fluid samples, compares those concentrations to standards concentrations, and provides oral administration of supplements selected from a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol to adjust gut microbiome components, repeating until the concentrations are within the standards. Dependent claims narrow the fluid sample matrix, the standards concentration generation, and the supplement combination requirements.

Stated Advantages

Documented Applications

No documented applications found