Compositions comprising peroxyacid and methods for producing and using the same
Inventors
Neas, Edwin D. • Skinner, John D.
Assignees
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Publication Number
US-11284621-B2
Publication Date
2022-03-29
Expiration Date
Abstract
The present invention provides methods for producing a non α-keto peracid that has lower toxicity and lower corrosivity. The present embodiments also provide methods and compositions for reducing microbes on a surface, methods, and compositions for preventing and reducing infectious vegetative bacteria on a substrate, and methods and compositions for treating a wound. In particular, compositions of the invention provide for a mixture of an α-keto peracid and a non α-keto peracid that works synergistically to reduce microbes on a surface, to prevent vegetative bacteria on a surface and to heal a wound in animals or humans.
Core Innovation
The invention relates to peroxyacid compositions that combine an α-keto peracid with a non-α-keto peroxyacid/peroxycarboxylic acid and optionally hydrogen peroxide. The peroxyacid system is expressed using α-keto peracids such as pyruvate peracid and other peroxy 2-oxo monocarboxylic or dicarboxylic acids, together with non-α-keto peracids including C1–C6 peracids and non-α-keto peroxycarboxylic acids such as peracetic acid, peroxy propionic acid, peroxybutanoic acid, peroxysuccinic acid, and peroxymalonic acid.
The document emphasizes synergistic antimicrobial, biofilm killing, and sporicidal activity, including activity in protein-rich environments. The compositions are described as having lower toxicity/corrosivity while maintaining effective microbe reduction and disinfection against vegetative bacteria, viruses, and mycobacteria.
The invention further describes producing non-α-keto peracids by contacting α-keto carboxylic acids with oxidizing agents to generate the non-α-keto peroxyacid, and supporting stable aqueous compositions. The document states a stability period of about 12 months and describes formulations for wound treatment as topical gels, solutions, lotions, irrigation gels, sprays, skin patches, or application granules.
Claims Coverage
The partial content identifies one independent claim with dependent claims that refine the oxidizing agent and additional components and/or narrow the wound treatment context. Across the independent claim, the main inventive features are the peroxyacid system with its parent carboxylic acid and oxidizing agent, the defined oxidizing agent-to-carboxylic acid ratio and concentration ranges, and the topical wound-treatment formulation formats.
Peroxyacid system with parent carboxylic acid and oxidizing agent
The composition consists essentially of a peroxyacid, a corresponding parent carboxylic acid of the peroxyacid, and an oxidizing agent.
Defined oxidizing agent-to-carboxylic acid ratio
The ratio of oxidizing agent to carboxylic acid is from about 0.5:1 to about 6:1.
Specified parent carboxylic acid and concentration ranges
The parent carboxylic acid is acetic acid in an amount of from 6.2 to about 120.4 mM, and the oxidizing agent is present in an amount of from about 7.2 to about 71.5 mM.
Topical wound-treatment formulation formats
The composition is formulated for wound treatment as a topical gel, liquid, lotion, irrigation gel, spray, skin patch or application granules.
Enumerated oxidizing agent selection
The oxidizing agent is at least one selected from a group of peroxide or superoxide compounds and combinations thereof.
Hydrogen peroxide as oxidizing agent
The oxidizing agent is hydrogen peroxide.
Specific component ratio value
The composition is defined by a specified ratio of 2:1.
Additional peroxyacid component selection
The composition further includes peroxymaleic acid and maleic acid.
Wound types selected for treatment
The composition is for treating a wound selected from a defined group including surgical wound, battle wound, accidental wound, thermal burn wound, chemical burn wound, chronic wound, decubitus ulcer, foot ulcer, venous ulcer, laser treatment wound, sunburn, an abrasion, or a combination thereof.
The claims coverage centers on a peroxyacid composition consisting essentially of a peroxyacid, its corresponding parent carboxylic acid, and an oxidizing agent, with a defined oxidizing agent-to-carboxylic acid ratio and specified acetic acid and oxidizing agent concentration ranges. The dependent claims refine the oxidizing agent, add specific peroxyacid components, constrain ratio values, and limit the intended wound treatment to a defined group of wound types and abrasion/burn/ulcer categories.
Stated Advantages
Synergistic antimicrobial activity.
Biofilm killing activity.
Sporicidal activity.
Activity in protein-rich environments.
Lower toxicity/corrosivity.
Suitability for topical wound treatment across many wound types.
Documented Applications
Topical wound treatment using formulations including topical gel, liquid, lotion, irrigation gel, spray, skin patch, and application granules.
Treatment of wounds selected from surgical wound, battle wound, accidental wound, thermal burn wound, chemical burn wound, chronic wound, decubitus ulcer, foot ulcer, venous ulcer, laser treatment wound, sunburn, abrasion, or combinations thereof.
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