Compositions and methods for the treatment and prevention of cognitive decline and preservation of neuronal function
Inventors
Assignees
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Publication Number
US-11278519-B2
Publication Date
2022-03-22
Expiration Date
Abstract
Described herein are compositions and methods for the treatment and prevention of cognitive decline in subjects. Generally, among other potential components, the compositions comprise Centella asiatica or an extract thereof; α-tocopherol or a derivative thereof; Ginseng or an extract thereof; a selenium compound, and α-lipoic acid. Also provided are methods of making such compositions.
Core Innovation
A multi-component composition is described for preventing or treating cognitive decline and for preserving neuronal function in a subject. The composition targets PLA2-related lipid peroxidation and oxidative stress, thereby addressing factors associated with cognitive decline and neuronal dysfunction.
The composition includes Centella asiatica extract comprising asiaticosides, d-α-tocopherol succinate as a lipid antioxidant, Panax ginseng root extract comprising ginsenosides, L-selenomethionine as a selenium compound, and α-lipoic acid as a glutathione level enhancer. The amount of asiaticosides is limited to 20% w/w or less of the composition, and the amount of ginsenosides is limited to 5% w/w or less of the composition.
The composition is formulated as a unit dose form for oral administration. The description further provides example oral formulations and unit dosage compositions including excipients, and reports human trial results across cognitive test domains.
Claims Coverage
The independent claim recites a unit-dose oral composition with five component materials and explicit quantitative constraints limiting asiaticosides and ginsenosides in weight percent. It also sets component dose ranges for each material and specifies that the composition is in a unit dose form.
Unit dose composition with quantified Centella asiatica, tocopherol succinate, ginseng, selenium and lipoic acid
A composition in a unit dose form comprising Centella asiatica extract comprising 20-80 mg of asiaticosides, d-α-tocopherol succinate in an amount of 40-200 mg, Ginseng root extract comprising 4-20 mg of ginsenosides, L-selenomethionine in an amount of 10-50 mcg, and α-lipoic acid in an amount of 25-200 mg.
Weight-percent limitation of asiaticosides and ginsenosides in the unit dose composition
The composition wherein the asiaticosides are present in an amount of 20% w/w or less of the composition and the ginsenosides are present in an amount of 5% w/w or less of the composition.
Overall, the claim coverage centers on the specific five-component unit-dose composition with explicit weight-percent limits for asiaticosides and ginsenosides.
Stated Advantages
The composition is described for preventing or treating cognitive decline and for preserving neuronal function in a subject.
The composition targets PLA2-related lipid peroxidation and oxidative stress.
Human trial results across cognitive test domains are reported.
Documented Applications
Preventing or treating cognitive decline.
Preserving neuronal function in a subject.
Normal age-related cognitive decline.
Multiple listed neurodegenerative/dementia indications.
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