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Assignees
Member
Kindeva Drug DeliveryKindeva Drug Delivery is a contract development and manufacturing organization specializing in advanced drug delivery systems including pulmonary, nasal, injectable, transdermal, and intradermal therapies. Services range from formulation and analytical development to commercial-scale, Annex 1-compliant GMP manufacturing across global facilities. The company brings integrated expertise in regulatory strategy, device engineering, process and technology transfer, and quality assurance, with a focus on sustainable solutions such as low-GWP propellants and microneedle patch platforms. Kindeva supports complex, patient-centric, and environmentally optimized therapies from product conception through commercialization.
Kindeva Drug Delivery is a contract development and manufacturing organization specializing in advanced drug delivery systems including pulmonary, nasal, injectable, transdermal, and intradermal therapies. Services range from formulation and analytical development to commercial-scale, Annex 1-compliant GMP manufacturing across global facilities. The company brings integrated expertise in regulatory strategy, device engineering, process and technology transfer, and quality assurance, with a focus on sustainable solutions such as low-GWP propellants and microneedle patch platforms. Kindeva supports complex, patient-centric, and environmentally optimized therapies from product conception through commercialization.
Publication Number
US-11273272-B2
Publication Date
2022-03-15
Expiration Date
Abstract
A breath-responsive inhaler having a trigger mechanism for triggering delivery of a medicament to a user, the trigger mechanism including a medicament source, having a primed position in which the inhaler is primed for use and an actuated position in which the medicament source is actuated to dispense a dose of medicament, a toggle mechanism for selectively permitting movement of the source from its primed position to its actuated position, the toggle mechanism comprising a vane positioned in the air flow path, the vane being pivoted about a vane pivot, and wherein the trigger mechanism is triggered by movement of the vane upon inhalation of the user to move the toggle mechanism between a primed condition in which the medicament source is maintained in its primed position by cooperation with the toggle mechanism and an actuated condition in which the toggle mechanism is disengaged from cooperation with the medicament source.
Core Innovation
The invention relates to a breath-responsive inhaler having a trigger mechanism and a trigger mechanism chassis locating the trigger mechanism within the inhaler, with an air flow path through which a user inhales. The trigger mechanism includes a medicament source having a medicament source primed position for priming the inhaler for use and a medicament source actuated position in which the medicament source dispenses a dose of medicament.
A toggle mechanism is provided with a vane positioned in the air flow path and pivoted about a vane pivot, and a toggle link pivotally mounted on the vane at a toggle link pivot proximal to the vane pivot. The toggle mechanism selectively permits movement of the medicament source from the medicament source primed position to the medicament source actuated position.
An actuation arm engages the medicament source and has an actuation arm primed position in which the toggle mechanism is in a primed condition and an actuation arm actuated position in which the toggle mechanism is in an actuated condition. In the primed condition, the actuation arm is maintained in the actuation arm primed position by engagement with the toggle mechanism through engagement with an upper end of the toggle link, with the upper end distal to the toggle link pivot.
In the actuated condition, the toggle mechanism is disengaged from the actuation arm, permitting the actuation arm to move to the actuation arm actuated position by movement of the upper end of the toggle link away from the actuation arm. The upper end of the toggle link defines a stub axle and the trigger mechanism chassis defines a toggle axle track, wherein the stub axle is moveable along the toggle axle track as the toggle mechanism moves between the primed condition and the actuated condition.
Claims Coverage
The document provides two independent claims covering a breath-responsive inhaler with an inhalation-actuated vane driving a toggle mechanism that maintains a medicament source in a primed position and then mechanically disengages to allow medicament delivery. The inventive features emphasize the vane- and toggle-link-based triggering arrangement, mechanical engagement and disengagement between an actuation arm and the toggle mechanism, and chassis/toggle-link axle-track motion defining primed versus actuated conditions, including a follow-through boss feature in the second independent claim.
Vane-actuated toggle selects medicament movement between primed and actuated positions
A breath-responsive inhaler in which inhalation moves a vane pivoted about a vane pivot to move a toggle mechanism between a primed condition and an actuated condition, where the toggle mechanism selectively permits the movement of the medicament source from the medicament source primed position to the medicament source actuated position.
Actuation arm engagement maintains primed condition and disengages in actuated condition
An actuation arm engaging the medicament source, having an actuation arm primed position maintained by engagement with the toggle mechanism through engagement with an upper end of the toggle link, and an actuated position in which the toggle mechanism is disengaged from the actuation arm to permit movement of the actuation arm by movement of the upper end of the toggle link away from the actuation arm.
Toggle link pivot proximal to vane pivot minimizes inhalatory effort
A toggle mechanism comprising a vane pivoted about a vane pivot and a toggle link pivotally mounted on the vane at a toggle link pivot proximal to the vane pivot.
Stub axle and chassis toggle axle track define primed versus actuated motion
The upper end of the toggle link defines a stub axle and the trigger mechanism chassis defines a toggle axle track, wherein the stub axle is moveable along the toggle axle track as the toggle mechanism moves between the primed condition and the actuated condition.
Follow-through boss provides selective engagement between actuation arm and toggle link
An actuation arm mounted for rotation about an arm pivot, defining a follow through boss for selective engagement with a toggle link, where the actuation arm has a primed position with the toggle mechanism in its primed condition and an actuated position with the toggle mechanism in its actuated condition, with engagement maintaining the actuation arm in the primed condition and disengagement permitting movement to the actuated position.
Across the two independent claims, the coverage centers on an inhalation-moved vane driving a toggle mechanism that mechanically maintains a medicament source in a primed position and then mechanically disengages to permit medicament delivery. The claims further require specific mechanical relationships between the actuation arm and the toggle mechanism, including engagement at an upper end of the toggle link, and define motion by using a stub axle moveable along a toggle axle track; the second independent claim adds an actuation arm defining a follow through boss for selective engagement.
Stated Advantages
Minimizes the inhalatory effort required to trigger the mechanism.
Provides mechanical disengagement in the actuated condition so the toggle mechanism is disengaged from the actuation arm, permitting actuation arm movement to an actuated position.
Documented Applications
Breath-responsive inhaler triggering for dispensing a dose of medicament from a medicament source having a medicament source primed position and a medicament source actuated position.
Pressurized metered dose inhaler (pMDI) having a medicament source as a canister.
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