Antithrombotic composition containing Polygonum cuspidatum sieb. et zucc. and Cinnamomum cassia blume
Inventors
Kim, Hyo Jung • KIM, Sun Gun • SO, Jai Hyun • LEE, Hwa Dong • KANG, Hye Ryung
Assignees
National Institute For Korean Medicine Development • Novmetapharma Co Ltd
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Publication Number
US-11273196-B2
Publication Date
2022-03-15
Expiration Date
Abstract
The present invention relates to an antithrombotic composition including Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume as active ingredients, and preferably includes an extract obtained by mixing Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume in a weight ratio of 1:2-2:1 and extracting the mixture. The composition of the present invention is highly effective in antithrombotic effects, identified as a platelet aggregation inhibitory effect, a thrombosis inhibitory effect, a thrombosis-delaying effect, and the like, and thus can be used as an effective herbal-medicine-based agent for preventing or treating thrombosis, an antithrombotic health food, and the like.
Core Innovation
An antithrombotic composition is described that comprises Polygonum cuspidatum (Sieb. et Zucc.) and Cinnamomum cassia (Blume) as active ingredients. The composition is preferably provided as a mixed extract prepared by mixing the herbs and extracting the mixture, and is positioned to inhibit platelet aggregation and suppress thrombosis effects.
The mixed extract is prepared by mixing Polygonum cuspidatum and Cinnamomum cassia in a weight ratio of 1:2 to 2:1, and is also exemplified with a 1:1 mixing ratio. An extraction is performed using 70% ethanol, followed by filtration, reduced-pressure concentration, and drying to obtain the extract.
The patent describes antithrombotic activity associated with the mixed extract, including platelet aggregation inhibition and thrombosis-related effects. In a collagen-induced rat platelet aggregation model and a FeCl3 animal model using carotid thrombus and blood-flow maintenance measurements, the mixed extract is described as maintaining blood flow and delaying thrombus formation compared with single extracts and a comparison product.
Claims Coverage
The independent claim set includes 1 independent claim. The claim coverage focuses on an antithrombotic composition using Polygonum cuspidatum and Cinnamomum cassia as active ingredients, with refinements regarding extract preparation and downstream use.
Antithrombotic composition using Polygonum cuspidatum and Cinnamomum cassia
An antithrombotic composition comprising Polygonum cuspidatum (Sieb. et Zucc.) and Cinnamomum cassia (Blume) as active ingredients.
Extract prepared from mixed herbs as active ingredients
The Polygonum cuspidatum (Sieb. et Zucc.) and Cinnamomum cassia (Blume) are provided as an extract prepared by mixing them in a weight ratio of 1:2 to 2:1 and then extracting.
Extract prepared by 1:1 mixing ratio and extraction
An antithrombotic composition in which the Polygonum cuspidatum (Sieb. et Zucc.) extract and the Cinnamomum cassia (Blume) extract are made by mixing them in a 1:1 weight ratio and performing extraction.
Ethanol extraction with specified solvent volume ratio and post-processing
An antithrombotic composition in which an extract from Polygonum cuspidatum (Sieb. et Zucc.) and Cinnamomum cassia (Blume) is obtained by using an extraction solvent at a 150-to-250 times volume ratio, immersing at 50°C to 70°C for 22 to 26 hours, then filtering the extract, concentrating under reduced pressure, and drying the concentrate.
Therapeutic agent for preventing or treating thrombosis using the composition
A therapeutic agent for preventing or treating thrombosis, wherein the agent comprises the composition of the antithrombotic composition.
Antithrombotic health food containing the composition
An antithrombotic health food that comprises the composition described.
Overall, the claim coverage centers on an antithrombotic composition containing Polygonum cuspidatum and Cinnamomum cassia, with refinements emphasizing mixed extracts, extraction conditions, and implementations as a therapeutic agent and an antithrombotic health food.
Stated Advantages
Inhibits platelet aggregation.
Suppresses thrombosis.
Delays thrombosis.
Documented Applications
Used for preventing or treating thrombosis as a therapeutic agent.
Provided as an antithrombotic health food containing the composition.
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