Methods of and systems for measuring analytes using batch calibratable test strips
Inventors
NOLAN, Bryan • Morgan, Thomas T. • Carnahan, David L.
Assignees
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Publication Number
US-11255840-B2
Publication Date
2022-02-22
Expiration Date
Abstract
Systems and methods for measuring analytes in fluid samples are disclosed. The systems and methods employ test strips which are generally comprised of a substrate, at least one electrical connection, at least one sensing chemistry and at least one additional layer. The test strips can be batch calibrated.
Core Innovation
The invention provides a system and method for determining the concentration of at least one analyte in a fluid sample using a base substrate with a first electrode pair and an active sensing chemistry in electrical communication with the first electrode pair. The conversion chamber is adapted for producing an altered analyte by oxidizing or reducing the at least one analyte in the fluid sample, and the active sensing chemistry is responsive to the altered analyte.
The active sensing chemistry forms an irreversible chemical bond with the altered analyte, and concentration is determined by measuring at least one of a voltage across the first electrode pair, a resistance across the first electrode pair, and a current flow across the first electrode pair. The conversion chamber and active sensing chemistry are combined to enable electrical response based on the altered analyte produced by oxidation or reduction.
In additional embodiments, the active sensing chemistry forms an irreversible chemical bond with the analyte and is configured as a coffee ring shape bridging the electrode pair. The sensing geometry is specified to be a coffee ring shape bridging the electrode pair, while concentration determination is performed by measuring at least one of voltage across the electrode pair, resistance across the electrode pair, and current flow across the electrode pair.
Claims Coverage
The independent claims cover three core inventive feature sets: a conversion chamber coupled to irreversible-bond electrochemical sensing and voltage/resistance/current measurement, a system version with the same conversion-and-irreversible-bond sensing architecture, and an irreversible-bond electrochemical sensing configuration where the sensing chemistry is a coffee ring shape bridging the electrode pair.
Conversion chamber produces an altered analyte for irreversible-bond electrochemical sensing
A method comprising a base substrate, a first electrode pair, a conversion chamber adapted for producing an altered analyte by oxidizing or reducing the at least one analyte, and active sensing chemistry in electrical communication with the first electrode pair, where the active sensing chemistry is responsive to the altered analyte and forms an irreversible chemical bond with the altered analyte.
Oxidizing or reducing conversion chamber with irreversible-bond active sensing chemistry for concentration
A system comprising a base substrate, a first electrode pair disposed over the substrate, a conversion chamber adapted for producing an altered analyte by oxidizing or reducing the at least one analyte, and active sensing chemistry in electrical communication with the first electrode pair, where the active sensing chemistry is responsive to the altered analyte and forms an irreversible chemical bond with the altered analyte.
Coffee ring-shaped active sensing chemistry bridging the electrode pair with irreversible binding
A system and method where the active sensing chemistry forms an irreversible chemical bond with the analyte and is a coffee ring shape bridging the electrode pair, and concentration is determined by measuring at least one of a voltage across the first electrode pair, a resistance across the first electrode pair, and a current flow across the first electrode pair.
Overall, the claims are centered on electrochemical sensing using active sensing chemistry that forms an irreversible chemical bond with either an altered analyte or the analyte directly, together with electrical measurement of voltage, resistance, and/or current across a first electrode pair. The scope further includes a specific active sensing geometry defined as a coffee ring shape bridging the electrode pair.
Stated Advantages
Documented Applications
No documented applications found
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