Bone gel sheet composition and method of manufacture
Inventors
Weston, Wendy W. • Gonzales, Silvia Daniela • Maldonado, Edgar S.
Assignees
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Publication Number
US-11253629-B2
Publication Date
2022-02-22
Expiration Date
Abstract
A bone gel composition consists of cortical bone. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the particle volume, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).
Core Innovation
The invention provides a bone gel composition consisting of cortical bone made from cut pieces of cortical bone that are freeze dried, ground into particles of a size up to 125 microns, demineralized, decanted, and mixed with plain sterile water at a volume ratio such that the water volume is at least twice the volume of the particles. The resulting mixture consists of sterile water and freeze-dried demineralized cortical bone particles.
The mixture of sterile water and freeze-dried demineralized particles is autoclaved under heat and pressure to form gelatin. The resulting bone gel is formed into sheets having a thickness in the range of 1 to 10 mm and formed into circular, round, or polygonal shapes.
The bone gel sheets are frozen for later use. The composition is based solely on freeze-dried, ground, demineralized cortical bone particles reconstituted with sterile water and is described as conformable into sheet-like structures intended to act as a binding agent and to facilitate handling and combination with other bone repair materials.
Claims Coverage
The claim coverage includes one independent claim defining the core bone gel composition and its preparation into gelatin sheets, with dependent claims refining sheet geometry and dimensional constraints.
Bone gel from demineralized cortical bone particles reconstituted in sterile water and autoclaved into gelatin sheets
A bone gel composition consisting of cortical bone made from cut pieces of cortical bone that has been freeze dried, ground into particles of a size up to 125 microns, demineralized, decanted, then mixed with plain sterile water to create a mixture with the water volume at least twice the volume of the particles, and the mixture is autoclaved under heat and pressure to form a gelatin.
Sheets of specified thickness and polygonal or circular shape formed from the bone gel and frozen for later use
The resulting bone gel is formed into sheets having a thickness in the range of 1 to 10 mm and formed into a circular, round, or polygonal shape, and the sheets are frozen for later use.
The claims center on producing gelatin from autoclaving a sterile-water and freeze-dried demineralized cortical bone particle mixture, then forming the gelatin into sheet-like bone gel with a defined thickness and circular or polygonal geometry, and freezing it for later use.
Stated Advantages
Conforms into sheet-like structures to serve as a binding agent for handling and combination with other bone repair materials.
Documented Applications
Facilitates combination with other bone repair materials, where the sheet-like bone gel acts as a binding agent and supports handling.
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